ArticleACS omega2020
Insight into the Loading and Release Properties of MCM-48/Biopolymer Composites as Carriers for 5-Fluorouracil: Equilibrium Modeling and Pharmacokinetic Studies.
Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Unlocking the potential of mesoporous silica nanoparticles: balancing biomedical applications and safety concerns.Drug delivery · 2026Review
- Chitosan/β-cyclodextrin nanocarriers enhance 5-fluorouracil efficacy against colorectal cancer via pH-responsive release and apoptosis modulation.Scientific reports · 2026Article
- Mesoporous Materials for Electrochemical Biosensors: From Broad Structure to Silica Film.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Sustainable wastewater decontamination from chlortetracycline using kaolin-alginate beads: adsorption mechanisms and practical applications.Royal Society open science · 2025Article
- Insight into loading, release, and anticancer activities of the methanol hybridized glauconite nano-sheets as a potential carrier of cisplatin: equilibrium and release kinetics.Frontiers in chemistry · 2025Article
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- Composite Hydrogel with Oleic Acid-Grafted Mesoporous Silica Nanoparticles for Enhanced Topical Delivery of Doxorubicin.Gels (Basel, Switzerland) · 2024Article
- Sustainable biofuel synthesis from non-edible oils: a mesoporous ZSM-5/Ni/Pt catalyst approach.RSC advances · 2024Article
- Article
- Insight into the integration effect of chitosan and β-cyclodextrin on the properties of zinc-phosphate/hydroxyapatite hybrid as delivery structures for 5-fluorouracil: loading and release profiles.Frontiers in chemistry · 2024Article
- Article
- Synthesis and characterization of Mg-hydroxyapatite and its cellulose hybridized structure as enhanced bio-carrier of oxaliplatin drug; equilibrium and release kinetics.RSC advances · 2023Article
- Article
- Synthesis and Characterization of Methoxy-Exfoliated Montmorillonite Nanosheets as Potential Carriers of 5-Fluorouracil Drug with Enhanced Loading, Release, and Cytotoxicity Properties.Molecules (Basel, Switzerland) · 2023Article
- Insights into the Effect of Chitosan and β-Cyclodextrin Hybridization of Zeolite-A on Its Physicochemical and Cytotoxic Properties as a Bio-Carrier for 5-Fluorouracil: Equilibrium and Release Kinetics Studies.Molecules (Basel, Switzerland) · 2023Article
- Synthesis and Characterization of β-Cyclodextrin-Hybridized Exfoliated Kaolinite Single Nanosheets as Potential Carriers of Oxaliplatin with Enhanced Loading, Release, and Cytotoxic Properties.Materials (Basel, Switzerland) · 2023Article
- Insight into the Morphological Properties of Nano-Kaolinite (Nanoscrolls and Nanosheets) on Its Qualification as Delivery Structure of Oxaliplatin: Loading, Release, and Kinetic Studies.Molecules (Basel, Switzerland) · 2023Article
- Article
- A comprehensive review on sustainable clay-based geopolymers for wastewater treatment: circular economy and future outlook.Environmental monitoring and assessment · 2023Review
- The Structure of Ordered Mesoporous Materials Synthesized from Aluminum Phyllosilicate Clay (Bentonite).Molecules (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of the integration between MCM-48 and some biopolymers (starch, chitosan, and β-cyclodextrin) on enhancing the pharmaceutical properties of MCM-48 as advanced carriers for the 5-fluorouracil drug was studied considering the loading capacities and the release profiles. The prepared carriers are MCM-48/chitosan (MCM/CH), MCM-48/starch composite (MCM/ST), and MCM-48/β-Cyclodextrin (MCM/CD). They emphasized excellent 5-Fu loading capacities of 141.2 mg/g (MCM-48), 156.6 mg/g (MCM/ST), 191 mg/g (MCM/CH), and 170 mg/g (MCM/CD), reflecting significant enhancement in the loading capacities. The kinetic and equilibrium investigation suggested physisorption loading of 5-Fu drug in a monolayer form for MCM-48, MCM/ST, and MCM/CH (Langmuir) and in a multilayer form for MCM/CD (Freundlich). This was supported by the estimated adsorption energies (0.23 kJ/mol (MCM-48), 0.26 kJ/mol (MCM/ST), 0.3 kJ/mol (MCM/CH), and 0.75 kJ/mol (MCM/CD)) and the thermodynamic parameters of free energy and enthalpy. The obtained release profiles for 80 h reflected significant controlling for the releasing behavior of MCM/48 on integrating its structure by adjusting the type of the selected polymer and its ratio. The pharmacokinetic modeling and the diffusion exponent from the Korsmeyer-Peppas model suggested non-Fickian transport behavior (a combination of erosion and diffusion releasing mechanism) for MCM/ST, MCM/CH, and MCM/CD and Fickian diffusion behavior (diffusion releasing mechanism) for MCM-48.
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Registered trials
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