Evidence map›Paper›PMID 32478244›Full record

ArticleACS omega2020

Two-Photon-Induced [2 + 2] Cycloaddition of Bis-thymines: A Biocompatible and Reversible Approach.

Monica Ricci, Martin G T A Rutten, Shuichi Toyouchi, Sepa Nanayakkara, Beatrice Fortuni, Raffaele Vitale, Susana Rocha, Daniela A Wilson, Johan Hofkens, Kei Saito and 1 more

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In one paragraph

Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Sub-Diffraction-Limit Dimension All-Plasmonic Optical Memory Using Non-Linear Photochromism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Monica RicciDepartment of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Heverlee, Belgium.
Martin G T A RuttenDepartment of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Heverlee, Belgium.
Shuichi ToyouchiDepartment of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Heverlee, Belgium.
Sepa NanayakkaraSchool of Chemistry, Monash University, Clayton, VIC 3800, Australia.
Beatrice FortuniDepartment of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Heverlee, Belgium.
Raffaele VitaleDepartment of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Heverlee, Belgium.
Susana RochaDepartment of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Heverlee, Belgium.
Daniela A WilsonInstitute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Johan HofkensDepartment of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Heverlee, Belgium.
Kei SaitoSchool of Chemistry, Monash University, Clayton, VIC 3800, Australia.
Hiroshi Uji-IDepartment of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Heverlee, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite having great value across a wide variety of scientific fields, two-photon polymerizations currently suffer from two significant problems: the need for photoinitiators, which generate toxic side products, and the irreversibility of the process. Hence, the design of a versatile approach that circumvents these issues represents a major scientific challenge. Herein, we report a two-photon absorption strategy where reversible [2 + 2] cycloaddition of bis-thymines was achieved without the need for any photoinitiator. The cycloaddition and cycloreversion reactions could be induced by simply changing the irradiation wavelength, and repeated writing and erasing cycles were performed. The simplicity, reversibility, and biocompatibility of this strategy open up a whole new toolbox for applications across a wide variety of scientific fields.

Identifiers

PMID32478244
PMCPMC7254774

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.