Evidence map›Paper›PMID 32478209›Full record

ArticleJACC. Basic to translational science2020

Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure.

Jhansi Dyavanapalli, Jeannette Rodriguez, Carla Rocha Dos Santos, Joan B Escobar, Mary Kate Dwyer, John Schloen, Kyung-Min Lee, Whitney Wolaver, Xin Wang, Olga Dergacheva and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Metabolism-Mediated Regulation of Brain-Heart Interactions.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Jhansi DyavanapalliDepartment of Pharmacology and Physiology, George Washington University, Washington, DC.
Jeannette RodriguezDepartment of Biomedical Engineering, George Washington University, Washington, DC.
Carla Rocha Dos SantosDepartment of Pharmacology and Physiology, George Washington University, Washington, DC.
Joan B EscobarDepartment of Pharmacology and Physiology, George Washington University, Washington, DC.
Mary Kate DwyerDepartment of Biomedical Engineering, George Washington University, Washington, DC.
John SchloenDepartment of Biomedical Engineering, George Washington University, Washington, DC.
Kyung-Min LeeDepartment of Pharmacology and Physiology, George Washington University, Washington, DC.
Whitney WolaverDepartment of Pharmacology and Physiology, George Washington University, Washington, DC.
Xin WangDepartment of Pharmacology and Physiology, George Washington University, Washington, DC.
Olga DergachevaDepartment of Pharmacology and Physiology, George Washington University, Washington, DC.
Lisete C MicheliniDepartment of Physiology, Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo/SP, Brazil.
Kathryn J SchunkeDepartment of Biomedical Engineering, George Washington University, Washington, DC.
Christopher F SpurneyChildren's National Heart Institute, Center for Genetic Medicine Research, Children's National Health System, Washington, DC.
Matthew W KayDepartment of Biomedical Engineering, George Washington University, Washington, DC.
David MendelowitzDepartment of Pharmacology and Physiology, George Washington University, Washington, DC.
George Washington University · USChildren's National · USUniversidade de São Paulo · BR

Funding

Restoration of Cardiac Parasympathetic Activity in Heart FailureR01HL133862 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI MENDELOWITZ, DAVID · 2016 to 2019
$1.8M
NHLBI NIH HHS R01 HL133862
6 · The paper itself

Abstract

This work shows long-term restoration of the hypothalamic oxytocin (OXT) network preserves OXT release, reduces mortality, cardiac inflammation, fibrosis, and improves autonomic tone and cardiac function in a model of heart failure. Intranasal administration of OXT in patients mimics the short-term changes seen in animals by increasing parasympathetic-and decreasing sympathetic-cardiac activity. This work provides the essential translational foundation to determine if approaches that mimic paraventricular nucleus (PVN) OXT neuron activation, such as safe, noninvasive, and well-tolerated intranasal administration of OXT, can be beneficial in patients with heart failure.

Indexed as

ANOVA, analysis of varianceCHO, Chinese hamster ovaryChR2, channelrhodopsinCNO, clozapine-N-oxideCVN, cardiac vagal neuronDMNX, dorsal motor nucleus of the vagusDREADD, designer receptors exclusively activated by designer drugheart failureHF, heart failureIL, interleukinLVDP, left ventricle- developed pressureLV, left ventricleOXT, oxytocinoxytocinparasympatheticPVN, paraventricular nucleus of the hypothalamusSD, standard deviationTAC, transascending aortic constriction

Identifiers

PMID32478209
PMCPMC7251188
OpenAlexW3028084390

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.