ReviewFrontiers in cardiovascular medicine2020
Neurohormones in the Pathophysiology of Vasovagal Syncope in Adults.
Review in Frontiers in cardiovascular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Sensor detection and pacing for impending reflex syncope.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Review
- Cardiac Acceleration Capacity and Vasovagal Syncope: Clinical Implications Beyond Pathophysiological Mechanisms.JACC. Asia · 2026Article
- Integrative cardiovascular dose-response to graded lower-body negative pressure.Experimental physiology · 2025Article
- Evaluation of the clinical value of heart rate variability in predicting vasovagal syncope.Frontiers in cardiovascular medicine · 2025Article
- Value of catecholamine levels in the differential diagnosis of vasovagal syncope and psychogenic pseudosyncope in children.Frontiers in pediatrics · 2024Article
- Pediatric syncope: pearls and pitfalls in history taking.Clinical and experimental pediatrics · 2023Article
- Predictive analysis of catecholamines and electrolytes for recurrence of orthostatic intolerance in children.Frontiers in pediatrics · 2023Article
- Vasovagal Syncope Is Associated with Variants in Genes Involved in Neurohumoral Signaling Pathways.Genes · 2022Article
- Article
- Gravitational Dose-Response Curves for Acute Cardiovascular Hemodynamics and Autonomic Responses in a Tilt Paradigm.Journal of the American Heart Association · 2022Article
- Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study.Clinical Medicine Insights. Cardiology · 2022Article
- Timing of Circulatory and Neurological Events in Syncope.Frontiers in cardiovascular medicine · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vasovagal syncope (VVS) is the most common cause of syncope across all age groups. Nonetheless, despite its clinical importance and considerable research effort over many years, the pathophysiology of VVS remains incompletely understood. In this regard, numerous studies have been undertaken in an attempt to improve insight into the evolution of VVS episodes and many of these studies have examined neurohormonal changes that occur during the progression of VVS events primarily using the head-up tilt table testing model. In this regard, the most consistent finding is a marked increase in epinephrine (Epi) spillover into the circulation beginning at an early stage as VVS evolves. Reported alterations of circulating norepinephrine (NE), on the other hand, have been more variable. Plasma concentrations of other vasoactive agents have been reported to exhibit more variable changes during a VVS event, and for the most part change somewhat later, but in some instances the changes are quite marked. The neurohormones that have drawn the most attention include arginine vasopressin [AVP], adrenomedullin, to a lesser extent brain and atrial natriuretic peptides (BNP, ANP), opioids, endothelin-1 (ET-1) and serotonin. However, whether some or all of these diverse agents contribute directly to VVS pathophysiology or are principally a compensatory response to an evolving hemodynamic crisis is as yet uncertain. The goal of this communication is to summarize key reported neurohumoral findings in VVS, and endeavor to ascertain how they may contribute to observed hemodynamic alterations during VVS.
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