ArticleFrontiers in bioengineering and biotechnology2020
Tagged Halloysite Nanotubes as a Carrier for Intercellular Delivery in Brain Microvascular Endothelium.
Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Therapeutic Oligonucleotides for Neurodegenerative Diseases: Aptamer Strategies and Clay Nanoparticle-Based Delivery.Chemical record (New York, N.Y.) · 2025Review
- Halloysite Nanotube-Based Delivery of Pyrazolo[3,4-Pharmaceutics · 2024Article
- Sustained release of vascular endothelial growth factor A and basic fibroblast growth factor from nanofiber membranes reduces oxygen/glucose deprivation-induced injury to neurovascular units.Neural regeneration research · 2024Article
- Clay Nanotubes Loaded with Diazepam or Xylazine Permeate the Brain through Intranasal Administration in Mice.International journal of molecular sciences · 2023Article
- Natural and Synthetic Clay Minerals in the Pharmaceutical and Biomedical Fields.Pharmaceutics · 2023Review
- Halloysite Nanotubes and Sepiolite for Health Applications.International journal of molecular sciences · 2023Review
- Nanotechnology and quantum science enabled advances in neurological medical applications: diagnostics and treatments.Medical & biological engineering & computing · 2022Review
- Nanoclays in medicine: a new frontier of an ancient medical practice.Materials advances · 2022Review
- Nanomaterials: A Review about Halloysite Nanotubes, Properties, and Application in the Biological Field.International journal of molecular sciences · 2022Review
- Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials.International journal of molecular sciences · 2021Review
- Efficient LRP1-Mediated Uptake and Low Cytotoxicity of Peptide L57 In Vitro Shows Its Promise as CNS Drug Delivery Vector.Journal of pharmaceutical sciences · 2021Article
- Sepiolite-Hydrogels: Synthesis by Ultrasound Irradiation and Their Use for the Preparation of Functional Clay-Based Nanoarchitectured Materials.Frontiers in chemistry · 2021Article
- Negative Feedback Role of Astrocytes in Shaping Excitation in Brain Cell Co-cultures.Frontiers in cellular neuroscience · 2021Article
- Cellular Analysis and Chemotherapeutic Potential of a Bi-Functionalized Halloysite Nanotube.Pharmaceutics · 2020Article
- The Immunomodulatory Potential of Copper and Silver Based Self-Assembled Metal Organic Biohybrids Nanomaterials in Cancer Theranostics.Frontiers in chemistry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurological disorders that are characterized by unpredictable seizures affect people of all ages. We proposed the use of nanocarriers such as halloysite nanotubes to penetrate the blood-brain barrier and effectively deliver the payload over an extended time period. These 50-nm diameter tubes are a natural biocompatible nanomaterial available in large quantities. We proved a prolonged gradual drug delivery mechanism by the nanotube encapsulating rhodamine isothiocyanate and then ionomycin into brain microvascular endothelial cells (BMVECs). Through delayed diffusion, the nanotubes effectively delivered the drug to the primary BMVECs without killing them, by binding and penetration in time periods of 1 to 24 h.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.