Evidence map›Paper›PMID 32477862›Full record

ArticleLeukemia research reports2020

Spontaneous remission of acute myeloid leukemia with NF1 alteration.

Terrence Bradley, Radames Adamo Zuquello, Luis E Aguirre, Nicholas Mackrides, Jennifer Chapman, Luisa Cimmino, Amber Thomassen, Justin Watts

Open access · goldAbstract read
In one paragraph

Article in Leukemia research reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Transient Spontaneous Remission of Acute Myeloid Leukemia with Mutated RUNX1: A Rare Report.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024
    Article
  5. What Can Trigger Spontaneous Regression of Breast Cancer?Diagnostics (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Terrence BradleyUniversity of Miami, Department of Medicine, Miami, FL, United States.
Radames Adamo ZuquelloUniversity of Miami, Department of Medicine, Miami, FL, United States.
Luis E AguirreUniversity of Miami, Department of Medicine, Miami, FL, United States.
Nicholas MackridesUniversity of Miami, Department of Pathology, Miami, FL, United States.
Jennifer ChapmanUniversity of Miami, Department of Pathology, Miami, FL, United States.
Luisa CimminoSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, United States.
Amber ThomassenSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, United States.
Justin WattsUniversity of Miami, Department of Medicine, Miami, FL, United States.
University of Miami · US

Funding

UM Calabresi Clinical Oncology Research Career Development AwardK12CA226330 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Alan Pollack · 2018 to 2026
$5.1M
NCI NIH HHS K12 CA226330
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is defined by the presence of ≥ 20% myeloblasts in the blood or bone marrow. Spontaneous remission (SR) of AML is a rare event, with few cases described in the literature. SR is generally associated with recovery from an infectious or immunologic process, and more recently possibly with clonal hematopoiesis. We review the literature and assess the trends associated with SR, and report a new case of a 58-year-old man with a morphologic diagnosis of AML associated with a severe gastrointestinal (GI) tract infection. The patient had an NF1 variant that was previously unreported in AML as the only clonal abnormality.  After treatment of the infection, the increased blast population subsided with no leukemia-directed therapy, and the patient has remained in a continuous, spontaneous complete remission for > 2 years.

Indexed as

Acute myeloid leukemiaClonal hematopoiesisLeukemoid reactionNF1 alterationSpontaneous remission

Identifiers

PMID32477862
PMCPMC7251391
OpenAlexW3024430078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.