ReviewThe Journal of innovations in cardiac rhythm management2018
Reversal Agents: What We Have and What We Can Expect.
Review in The Journal of innovations in cardiac rhythm management, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Stroke Prevention in Patients with Atrial Fibrillation.The Journal of innovations in cardiac rhythm management · 2018Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical trials in patients with atrial fibrillation have demonstrated that non-vitamin K antagonist oral anticoagulants [novel oral anticoagulants (NOACs)] are markedly safer than warfarin with respect to serious bleeding-especially intracranial hemorrhage, the most feared and devastating complication of anticoagulant therapy. Registries and large retrospective database studies have confirmed these findings. Additionally, patients who do experience bleeding while taking NOACs have similar or better outcomes than do patients on warfarin. However, despite these data, many physicians and patients have been reluctant to embrace NOAC use due to their perception that they are not able to effectively manage patients who present with bleeding, particularly without a specific reversal agent or antidote on-hand. With the approval of the first NOAC-specific reversal agent and with others in late-stage clinical development, it is helpful to review how these agents may fit in the framework of managing NOAC-related bleeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.