Evidence map›Paper›PMID 32477621›Full record

ArticleAMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science2020

GenomeForest: An Ensemble Machine Learning Classifier for Endometriosis.

Sadia Akter, Dong Xu, Susan C Nagel, John J Bromfield, Katherine E Pelch, Gilbert B Wilshire, Trupti Joshi

Open access · greenAbstract read
In one paragraph

Article in AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sadia AkterInformatics Institute.
Dong XuInformatics Institute.
Susan C NagelOB/GYN and Women's Health , University of Missouri, Columbia, MO.
John J BromfieldOB/GYN and Women's Health , University of Missouri, Columbia, MO.
Katherine E PelchOB/GYN and Women's Health , University of Missouri, Columbia, MO.
Gilbert B WilshireBoone Hospital Center, Columbia, MO.
Trupti JoshiInformatics Institute.
Boone Hospital Center · USUniversity of Missouri Health System · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Project 4: Human Endometrial Programming for Successful ImplantationP50HD055764 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GIUDICE, LINDA C · 2014 to 2022
$16.4M
Trophoblast Differentiation in In Vivo and In Vitro Fertilized EmbryosU54HD055764 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FISHER, SUSAN J. · 2007 to 2013
$11.5M
Global methylation profile in endometrium of endometriosis patientsR21ES020039 · NIEHS · UNIVERSITY OF MISSOURI-COLUMBIA · PI NAGEL, SUSAN C · 2011 to 2012
$417k
NCATS NIH HHS UL1 TR002345NICHD NIH HHS P50 HD055764NICHD NIH HHS U54 HD055764NIEHS NIH HHS R21 ES020039
6 · The paper itself

Abstract

Endometriosis is a complex and high impact disease affecting 176 million women worldwide with diagnostic latency between 4 to 11 years due to lack of a definitive clinical symptom or a minimally invasive diagnostic method. In this study, we developed a new ensemble machine learning classifier based on chromosomal partitioning, named GenomeForest and applied it in classifying the endometriosis vs. the control patients using 38 RNA-seq and 80 enrichment-based DNA-methylation (MBD-seq) datasets, and computed performance assessment with six different experiments. The ensemble machine learning models provided an avenue for identifying several candidate biomarker genes with a very high F1 score; a near perfect F1 score (0.968) for the transcriptomics dataset and a very high F

Identifiers

PMID32477621
PMCPMC7233069
OpenAlexW3030731582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.