Evidence map›Paper›PMID 32477489›Full record

ArticleCell & bioscience2020

Intestinal homeostasis: a communication between life and death.

Lingyu Bao, Bingyin Shi, Yun-Bo Shi

Open access · goldAbstract read
In one paragraph

Article in Cell & bioscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Circadian clock-gated cell renewal controls time-dependent changes in taste sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Lingyu Bao1Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, No.277, Yanta West Road, Xi'an, Shaanxi, 710061 People's Republic of China.
Bingyin Shi1Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, No.277, Yanta West Road, Xi'an, Shaanxi, 710061 People's Republic of China.
Yun-Bo Shi2Section on Molecular Morphogenesis, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD 20892 USA.ORCID 0000-0002-6330-0639
First Affiliated Hospital of Xi'an Jiaotong University · CNNational Institutes of Health · US

Funding

Regulation of stem cell development during tissue remodelingZIAHD008858 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SHI, YUN-BO · 2009 to 2025
$15.2M
6 · The paper itself

Abstract

Organ homeostasis is essential for organ physiology and disease prevention. In adult vertebrates, the intestinal epithelium is maintained through constant cell proliferation in the crypt and apoptosis of differentiated epithelial cells, mainly at the tip of the villus. Based on studies with altered cell proliferation and tissue damage in the adult mouse intestine, we hypothesize that there is a communication between cell proliferation in the crypt and cell death on the villus, likely via cell-cell and cell-ECM (extracellular matrix) interactions, to coordinate the rate of cell proliferation and death, thus ensuring epithelial homeostasis.

Indexed as

Adult organ specific stem cellApoptosisCell-ECM interactionCell proliferation and differentiationOrgan homeostasis

Identifiers

PMID32477489
PMCPMC7236522
OpenAlexW3029263384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.