ReviewFrontiers in immunology2020
Postnatal Involution and Counter-Involution of the Thymus.
Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 52 citations in OpenAlex.
- CD9Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T-Cell Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Blood-based immunophenotyping of T cell profiles in patients with neurodegenerative disorders.Alzheimer's research & therapy · 2026Article
- RNA-binding proteins Zfp36l1 and Zfp36l2 protect against premature thymic involution.Cellular & molecular immunology · 2026Article
- From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology.Immunological reviews · 2026Review
- Article
- Age-related thymic involution: Mechanistic insights and rejuvenating approaches to restore immune function.Science advances · 2026Review
- Thymic regeneration and tumor immunotherapy.Frontiers in immunology · 2026Review
- Multifaceted regulation of thymic tolerance by pattern recognition cascades.Frontiers in immunology · 2026Review
- Mechanism and intervention strategy of thymus atrophy in cancer immunotherapy.American journal of cancer research · 2026Review
- Single-cell analysis of human thymus and peripheral blood unveils the dynamics of T cell development and aging.Nature aging · 2025Article
- Early life stress induces social behavioral deficits and peripheral biomarker alterations in adolescence that perpetuate intergenerationally.bioRxiv : the preprint server for biology · 2025Article
- Ectopic cervical thymus in a child: A rare neck mass case report.International journal of surgery case reports · 2025Article
- Bioprinting revolution: Innovative design of 3D bioactive scaffolds for living organs and transdermal tissues.Bioengineering & translational medicine · 2025Review
- Cocaine abuse and its impact on the thymus and spleen.Histology and histopathology · 2025Review
- Heterogeneity of thymic output in the elderly and its association with sex and smoking.JCI insight · 2025Article
- The immune response of Boschveld chickens to a Newcastle disease vaccination program designed for commercial layers.Tropical animal health and production · 2025Article
- FGF21 keeps the thymus young.Nature aging · 2025Article
- Enhanced paracrine action of FGF21 in stromal cells delays thymic aging.Nature aging · 2025Article
- Aging immunity: unraveling the complex nexus of diet, gut microbiome, and immune function.Immunometabolism (Cobham, Surrey) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Thymus involution occurs in all vertebrates. It is thought to impact on immune responses in the aged, and in other clinical circumstances such as bone marrow transplantation. Determinants of thymus growth and size are beginning to be identified. Ectopic expression of factors like cyclin D1 and Myc in thymic epithelial cells (TEC)s results in considerable increase in thymus size. These models provide useful experimental tools that allow thymus function to be understood. In future, understanding TEC-specific controllers of growth will provide new approaches to thymus regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.