Evidence map›Paper›PMID 32477354›Full record

ArticleFrontiers in immunology2020

Scald Injury-Induced T Cell Dysfunction Can Be Mitigated by Gr1

Nadine Beckmann, Franziska Huber, Marc Hanschen, Barbara St Pierre Schneider, Vanessa Nomellini, Charles C Caldwell

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Nadine BeckmannDivision of Research, Department of Surgery, University of Cincinnati, Cincinnati, OH, United States.
Franziska HuberExperimental Trauma Surgery, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Marc HanschenExperimental Trauma Surgery, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Barbara St Pierre SchneiderProfessor, School of Nursing, University of Nevada, Las Vegas, NV, United States.
Vanessa NomelliniDivision of Research, Shriner's Hospital for Children Cincinnati, Cincinnati, OH, United States.
Charles C CaldwellDivision of Research, Department of Surgery, University of Cincinnati, Cincinnati, OH, United States.
Technical University of Munich · DEUniversity of Cincinnati · USUniversity of Cincinnati Medical Center · USUniversity of Nevada, Las Vegas · US

Funding

Mechanisms of Altered Neutrophil Trafficking in the Persistent Inflammation, Immunosuppression and Catabolism SyndromeK08GM131284 · NIGMS · UNIVERSITY OF CINCINNATI · PI NOMELLINI, VANESSA · 2018 to 2019
$399k
NIGMS NIH HHS K08 GM131284
6 · The paper itself

Abstract

Infection is a common and severe complication of burn injury: Sepsis accounts for 47% of postburn mortality. Burn-induced T cell suppression likely contributes to the increased infection susceptibility in burn patients. However, little is known about the kinetics of T cell dysfunction after burn and its underlying mechanisms. In this study, we show in a murine scald injury model that T cell activation of both CD4

Indexed as

AnimalsAntigens, DifferentiationAntigens, LyBurnsCD47 AntigenCells, CulturedImmune ToleranceLymphocyte DepletionMaleMiceMice, Inbred StrainsMyeloid-Derived Suppressor CellsReceptors, ImmunologicReticulocytesSignal TransductionT-LymphocytesAntigens, DifferentiationAntigens, LyCD47 AntigenLy6G antigen, mouseReceptors, ImmunologicSIRPA protein, humanadaptive immunityimmature reticulocytesimmune-checkpoint inhibitorsimmunosuppressionmyeloid-derived suppressor cells

Identifiers

PMID32477354
PMCPMC7232553
OpenAlexW3022770946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.