Evidence map›Paper›PMID 32477334›Full record

ReviewFrontiers in immunology2020

Immunogenicity of Protein Therapeutics: A Lymph Node Perspective.

Kristy Fu, Kylie March, Aikaterini Alexaki, Giulia Fabozzi, Eirini Moysi, Constantinos Petrovas

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Porous silicon and silica carriers for delivery of peptide therapeutics.Drug delivery and translational research · 2024
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Virus-like Particles: Fundamentals and Biomedical Applications.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kristy FuTissue Analysis Core, Immunology Laboratory, Vaccine Research Center, NIAID, National Institutes of Health (NIH), Bethesda, MD, United States.
Kylie MarchTissue Analysis Core, Immunology Laboratory, Vaccine Research Center, NIAID, National Institutes of Health (NIH), Bethesda, MD, United States.
Aikaterini AlexakiCenter for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.
Giulia FabozziTissue Analysis Core, Immunology Laboratory, Vaccine Research Center, NIAID, National Institutes of Health (NIH), Bethesda, MD, United States.
Eirini MoysiTissue Analysis Core, Immunology Laboratory, Vaccine Research Center, NIAID, National Institutes of Health (NIH), Bethesda, MD, United States.
Constantinos PetrovasTissue Analysis Core, Immunology Laboratory, Vaccine Research Center, NIAID, National Institutes of Health (NIH), Bethesda, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The continuous development of molecular biology and protein engineering technologies enables the expansion of the breadth and complexity of protein therapeutics for

Indexed as

AnimalsAntibody FormationAntigensB-LymphocytesDrug TherapyGerminal CenterHumansImmunity, HumoralLymph NodesMiceAntigensADAB cellsfolliclegerminal centerTfh celltherapeutics

Identifiers

PMID32477334
PMCPMC7240201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.