Evidence map›Paper›PMID 32477273›Full record

ArticleFrontiers in endocrinology2020

The Role of Glucocorticoid Receptor and Oxytocin Receptor in the Septic Heart in a Clinically Relevant, Resuscitated Porcine Model With Underlying Atherosclerosis.

Tamara Merz, Nicole Denoix, Daniela Wigger, Christiane Waller, Martin Wepler, Sabine Vettorazzi, Jan Tuckermann, Peter Radermacher, Oscar McCook

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Relationships Between HAntioxidants (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Roles of the Oxytocin Receptor (OXTR) in Human Diseases.International journal of molecular sciences · 2023
    Review
  7. HBiomolecules · 2022
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. HJournal of clinical medicine · 2021
    Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tamara MerzUlm University Medical Center, Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm, Germany.
Nicole DenoixClinic for Psychosomatic Medicine and Psychotherapy, Ulm University Medical Center, Ulm, Germany.
Daniela WiggerClinic for Psychosomatic Medicine and Psychotherapy, Ulm University Medical Center, Ulm, Germany.
Christiane WallerDepartment of Psychosomatic Medicine and Psychotherapy, Nuremberg General Hospital, Paracelsus Medical University, Nuremberg, Germany.
Martin WeplerUlm University Medical Center, Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm, Germany.
Sabine VettorazziInstitute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany.
Jan TuckermannInstitute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany.
Peter RadermacherUlm University Medical Center, Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm, Germany.
Oscar McCookUlm University Medical Center, Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm, Germany.
Universität Ulm · DENuremberg Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathophysiology of sepsis-induced myocardial dysfunction is not resolved to date and comprises inflammation, barrier dysfunction and oxidative stress. Disease-associated reduction of tissue cystathionine-γ-lyase (CSE) expression, an endogenous H

Indexed as

Gene Expression RegulationAnimalsAtherosclerosisCystathionine gamma-LyaseDisease Models, AnimalHeart DiseasesHydrogen SulfideHypercholesterolemiaMaleOxidative StressReceptors, GlucocorticoidReceptors, OxytocinShock, SepticSignal TransductionSwineCystathionine gamma-LyaseHydrogen SulfideReceptors, GlucocorticoidReceptors, Oxytocincystathionine-γ-lyaseglucocorticoid receptorheartinflammationoxidative stressoxytocin receptorsepsis

Identifiers

PMID32477273
PMCPMC7239997
OpenAlexW3025525403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.