Evidence map›Paper›PMID 32477237›Full record

ArticleFrontiers in neurology2020

Sleep Spindles and Fragmented Sleep as Prodromal Markers in a Preclinical Model of LRRK2-G2019S Parkinson's Disease.

Lindsey M Crown, Mitchell J Bartlett, Jean-Paul L Wiegand, Allison J Eby, Emily J Monroe, Kathleen Gies, Luke Wohlford, Matthew J Fell, Torsten Falk, Stephen L Cowen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lindsey M CrownDepartment of Psychology, University of Arizona, Tucson, AZ, United States.
Mitchell J BartlettDepartment of Neurology, University of Arizona, Tucson, AZ, United States.
Jean-Paul L WiegandGraduate Interdisciplinary Program in Neuroscience, University of Arizona, Tucson, AZ, United States.
Allison J EbyDepartment of Physiology, University of Arizona, Tucson, AZ, United States.
Emily J MonroeDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, United States.
Kathleen GiesDepartment of Psychology, University of Arizona, Tucson, AZ, United States.
Luke WohlfordCollege of Medicine, University of Arizona, Phoenix, AZ, United States.
Matthew J FellMerck & Co., Inc., Boston, MA, United States.
Torsten FalkDepartment of Neurology, University of Arizona, Tucson, AZ, United States.
Stephen L CowenDepartment of Psychology, University of Arizona, Tucson, AZ, United States.
University of Arizona · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep disturbances co-occur with and precede the onset of motor symptoms in Parkinson's disease (PD). We evaluated sleep fragmentation and thalamocortical sleep spindles in mice expressing the p.G2019S mutation of the leucine-rich repeat kinase 2 (

Indexed as

biomarkerEEGLRRK2Parkinson's diseaseprodromalsleep fragmentationsleep spindles

Identifiers

PMID32477237
PMCPMC7232828
OpenAlexW3021532476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.