ArticleFrontiers in psychiatry2020
State-Independent Microstructural White Matter Abnormalities in Major Depressive Disorder.
Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Structural brain correlates in major depressive disorder, anxiety disorders, and post-traumatic stress disorder: a diffusion tensor imaging meta-analysis.Psychological medicine · 2025Pooled it
- Brain connectivity in major depressive disorder: a precision component of treatment modalities?Translational psychiatry · 2023Pooled it
- Neuroplastic white matter changes in patients with major depression following lysergic acid diethylamide treatment.Cell reports. Medicine · 2026Trial
- Macromolecular Proton Fraction Reveals Divergent White Matter Myelination in Bipolar Disorder and Unipolar Recurrent Depression.Bioengineering (Basel, Switzerland) · 2026Article
- Longitudinal associations between white matter integrity, early life adversities, and treatment response following cognitive-behavioral therapy in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- White matter integrity and medication response to antidepressants in major depressive disorder: a review of the literature.Frontiers in psychiatry · 2023Review
- Intrinsic Organization of Occipital Hubs Predicts Depression: A Resting-State fNIRS Study.Brain sciences · 2022Article
- State-Independent and -Dependent Structural Connectivity Alterations in Depression.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEven with continuous antidepressant treatment, residual symptoms and the risk of relapse can persist in remitted major depressive disorder (MDD) patients. Hence, having a clear recognition of the persistent abnormalities of the underlying neural substrate in MDD through a longitudinal investigation is of great importance.
methodsA total of 127 adult medication-free MDD patients with an acute depressive episode and 118 matched healthy controls (HCs) underwent diffusion tensor imaging. Over a 6-month treatment course, 62 remitted patients underwent a second scan. Remission was defined as a 24-item Hamilton Depression Rating Scale (HAMD
resultsSignificant FA reductions in the left insula, left middle occipital gyrus, right thalamus, left pallidum and left precuneus were observed in current MDD (cMDD) patients compared with HCs. Moreover, significant FA reductions in the left insula were observed in remitted (rMDD) patients compared to HCs. However, no significant differences in FA values were found when comparing cMDD and rMDD patients.
conclusionsThe abnormalities in the insula showed state-independent characteristics, while the abnormalities in the middle occipital gyrus, thalamus, pallidum and precuneus seemed to be state-dependent impairments in MDD patients.
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