ArticleMicrobial biotechnology2021
One major facilitator superfamily transporter is responsible for propionic acid tolerance in Pseudomonas putida KT2440.
Article in Microbial biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Phylum-wide propionate degradation and its potential connection to poly-gamma-glutamate biosynthesis in Candidatus Cloacimonadota phylum.The ISME journal · 2026Article
- Genetically encoded biosensor enabled mining, characterisation and engineering of aromatic acid MFS transporters.Journal of biological engineering · 2025Article
- Itaconic acid production from corn stover hydrolysates for a newly isolated Aspergillus terreus through adaptive evolution.Bioprocess and biosystems engineering · 2025Article
- Cold Plasma Treatment Facilitated the Conversion of Lignin-Derived Aldehyde for Pseudomonas putida.Applied biochemistry and biotechnology · 2025Article
- Evaluation of the Robustness Under Alkanol Stress and Adaptability of Members of the New GenusMicroorganisms · 2024Article
- Improvement in Salt Tolerance Ability ofBiology · 2024Article
- Syntrophic entanglements for propionate and acetate oxidation under thermophilic and high-ammonia conditions.The ISME journal · 2023Article
- Identification and expression of small multidrug resistance transporters in early-branching anaerobic fungi.Protein science : a publication of the Protein Society · 2023Article
- New insight into the production improvement and resource generation of chaetoglobosin A in Chaetomium globosum.Microbial biotechnology · 2022Article
- Enhancing biofuels production by engineering the actin cytoskeleton in Saccharomyces cerevisiae.Nature communications · 2022Article
- Transporter Engineering in Microbial Cell Factory Boosts Biomanufacturing Capacity.Biodesign research · 2022Review
- Unraveling the mechanism of furfural tolerance in engineeredFrontiers in microbiology · 2022Article
- Unravelling the thioesterases responsible for propionate formation in engineered Pseudomonas putida KT2440.Microbial biotechnology · 2021Article
- One major facilitator superfamily transporter is responsible for propionic acid tolerance in Pseudomonas putida KT2440.Microbial biotechnology · 2021Article
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Authors and funding
6 authors.
Funding
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Abstract
Propionic acid (PA) has been widely used as a food preservative and chemical intermediate in the agricultural and pharmaceutical industries. Environmental and friendly biotechnological production of PA from biomass has been considered as an alternative to the traditional petrochemical route. However, because PA is a strong inhibitor of cell growth, the biotechnological host should be not only able to produce the compound but the host should be robust. In this study, we identified key PA tolerance factors in Pseudomonas putida KT2440 strain by comparative transcriptional analysis in the presence or absence of PA stress. The identified major facilitator superfamily (MFS) transporter gene cluster of PP_1271, PP_1272 and PP_1273 was experimentally verified to be involved in PA tolerance in P. putida strains. Overexpression of this cluster improved tolerance to PA in a PA producing strain, what is useful to further engineer this robust platform not only for PA synthesis but for the production of other weak acids.
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