ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020
Tc-99m-pyrophosphate scintigraphy for the diagnosis of ATTR cardiac amyloidosis: Comparison of quantitative and semi-quantitative approaches.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Diagnostic performance of CMR, SPECT, and PET imaging for the detection of cardiac amyloidosis: a meta-analysis.BMC cardiovascular disorders · 2021Pooled it
- QuantitativeEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Article
- Current barriers and recommendations on the diagnosis of transthyretin amyloid cardiomyopathy: a Delphi study.Frontiers in cardiovascular medicine · 2024Article
- Transthyretin amyloid cardiomyopathy disease burden quantified usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prevalence of transthyretin amyloidosis among heart failure patients with preserved ejection fraction in Japan.ESC heart failure · 2023Article
- Hot spot imaging in cardiovascular diseases: an information statement from SNMMI, ASNC, and EANM.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- A Review of Current and Evolving Imaging Techniques in Cardiac Amyloidosis.Current treatment options in cardiovascular medicine · 2023Article
- FDG PET in infective endocarditis: There are still horizons to conquer.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Tc-99m pyrophosphate scintigraphy for cardiac amyloidosis: concordance between planar and SPECT/CT imaging.The international journal of cardiovascular imaging · 2022Article
- Comparison of 18F-sodium fluoride positron emission tomography imaging and 99mTc-pyrophosphate in cardiac amyloidosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Enhanced quantitative method for the diagnosis of grade 1 cardiac amyloidosis inScientific reports · 2022Article
- Review
- Pitfalls of the Semi-Quantitative AnalyzingDiagnostics (Basel, Switzerland) · 2022Article
- Multimodality Imaging in the Evaluation and Prognostication of Cardiac Amyloidosis.Frontiers in cardiovascular medicine · 2022Review
- Transthyretin cardiac amyloidosis: a review of the nuclear imaging findings with emphasis on the radiotracers mechanisms.Annals of nuclear medicine · 2021Review
- Diagnosing Transthyretin Cardiac Amyloidosis by Technetium Tc 99m Pyrophosphate: A Test in Evolution.JACC. Cardiovascular imaging · 2021Article
- A cardiology fellow's take-home points from ASNC's Webinar: Cases in Tc 99m-PYP evaluation of ATTR cardiac amyloidosis - interpretation and reporting.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundATTR cardiac amyloidosis (CA) can be diagnosed with Tc-99m-PYP scintigraphy. There are two recommended interpretative approaches: the quantitative heart-to-contralateral lung ratio (H/CL) at 1 hour and the semi-quantitative visual system at 3 hours. This study's aim was to compare both approaches and to apply the semi-quantitative method at 1 hour.
methodsTc-99m-PYP scans of 122 consecutive subjects were reviewed using both approaches. On 1 hour planar images, regions of interest were drawn over the heart and contralateral chest to determine H/CL. Myocardial uptake was graded on 1 and 3 hour SPECT images according to the semi-quantitative method. Concordance was examined using kappa statistics.
results31, 10, and 81 studies were positive, negative, and equivocal, respectively, for ATTR-CA using the H/CL approach. Using the grading system, 35, 77, and 10 scans were positive, negative, and equivocal, respectively. The quantitative approach led to a significantly higher proportion of equivocal studies compared to the semi-quantitative approach (P < .0001). These approaches yielded discordant results in 2 subjects; biopsy results were concordant with SPECT grade. 1 and 3 hour SPECT grades provided concordant result in 99% of cases.
conclusionsThe H/CL approach resulted in a high proportion of equivocal studies. Using SPECT imaging, the semi-quantitative approach minimized this proportion and showed high concordance at 1 and 3 hours.
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