Evidence map›Paper›PMID 32476096›Full record

ArticleMolecular and cellular pediatrics2020

Modulation of CYP2E1 metabolic activity in a cohort of confirmed caffeine ingesting pregnant women with preterm offspring.

M R Alcorta-García, C N López-Villaseñor, G Sánchez-Ferrer, H Flores-Mendoza, F Castorena-Torres, M A Aguilar-Torres, C M Sepúlveda-Treviño, J A Hernández-Hernández, R C López-Sánchez, V J Lara-Díaz

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In one paragraph

Article in Molecular and cellular pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

M R Alcorta-GarcíaTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Avenida Ignacio Morones Prieto 3000 poniente, Colonia Doctores, CP 64710, Monterrey, Nuevo León, México.ORCID https://orcid.org/0000-0001-5909-4871
C N López-VillaseñorTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Avenida Ignacio Morones Prieto 3000 poniente, Colonia Doctores, CP 64710, Monterrey, Nuevo León, México.ORCID https://orcid.org/0000-0002-5692-4363
G Sánchez-FerrerTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Avenida Ignacio Morones Prieto 3000 poniente, Colonia Doctores, CP 64710, Monterrey, Nuevo León, México.
H Flores-MendozaTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Avenida Ignacio Morones Prieto 3000 poniente, Colonia Doctores, CP 64710, Monterrey, Nuevo León, México.
F Castorena-TorresTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Avenida Ignacio Morones Prieto 3000 poniente, Colonia Doctores, CP 64710, Monterrey, Nuevo León, México.ORCID https://orcid.org/0000-0002-1157-0004
M A Aguilar-TorresTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Avenida Ignacio Morones Prieto 3000 poniente, Colonia Doctores, CP 64710, Monterrey, Nuevo León, México.
C M Sepúlveda-TreviñoTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Avenida Ignacio Morones Prieto 3000 poniente, Colonia Doctores, CP 64710, Monterrey, Nuevo León, México.
J A Hernández-HernándezTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Avenida Ignacio Morones Prieto 3000 poniente, Colonia Doctores, CP 64710, Monterrey, Nuevo León, México.ORCID https://orcid.org/0000-0003-4556-7257
R C López-SánchezTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Avenida Ignacio Morones Prieto 3000 poniente, Colonia Doctores, CP 64710, Monterrey, Nuevo León, México.ORCID https://orcid.org/0000-0002-6200-1397
V J Lara-DíazTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Avenida Ignacio Morones Prieto 3000 poniente, Colonia Doctores, CP 64710, Monterrey, Nuevo León, México. lara-diaz.vj@tec.mx.ORCID https://orcid.org/0000-0002-1498-8561
Tecnológico de Monterrey · MX

Funding

Instituto Tecnológico y de Estudios Superiores de Monterrey CAT00222
6 · The paper itself

Abstract

backgroundTo ascertain interactions of caffeine ingestion, food, medications, and environmental exposures during preterm human gestation, under informed consent, we studied a cohort of Mexican women with further preterm offspring born at ≤ 34 completed weeks. At birth, blood samples were taken from mothers and umbilical cords to determine caffeine and metabolites concentrations and CYP1A2 (rs762551) and CYP2E1 (rs2031920, rs3813867) polymorphisms involved in caffeine metabolism.

resultsIn 90 pregnant women who gave birth to 98 preterm neonates, self-informed caffeine ingestion rate was 97%, laboratory confirmed rate was 93 %. Theobromine was the predominant metabolite found. Consumption of acetaminophen correlated significantly with changes in caffeine metabolism (acetaminophen R

conclusionEnvironmental exposures, especially acetaminophen ingestion during human preterm pregnancy, can modulate CYP2E1 metabolic activity.

Indexed as

CaffeineCytochrome P-450 CYP1A2 inducersCytochrome P-450 CYP1A2 inhibitorsCytochrome P-450 CYP2E1 inducersCytochrome P-450 CYP2E1 inhibitorsCytochrome P-450 Enzyme SystemInfant, PrematurePremature birth

Identifiers

PMID32476096
PMCPMC7261717
OpenAlexW3029244834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.