ReviewJournal of molecular neuroscience : MN2020
Therapeutic and Diagnostic Potential of microRNAs in Vascular Cognitive Impairment.
Review in Journal of molecular neuroscience : MN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- MicroRNA-140-5p and cystatin-C expression in patients with vascular cognitive impairment and its clinical value.Biomarkers in medicine · 2025Article
- Insights into the Role of microRNAs as Clinical Tools for Diagnosis, Prognosis, and as Therapeutic Targets in Alzheimer's Disease.International journal of molecular sciences · 2024Review
- Control of Selective mRNA Translation in Neuronal Subcellular Compartments in Health and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Electroacupuncture of the Baihui and Shenting acupoints for vascular dementia in rats through the miR-81/IL-16/PSD-95 pathway.Annals of translational medicine · 2022Article
- Crosstalk Among NLRP3 Inflammasome, ETNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Promotive role of microRNA‑150 in hippocampal neurons apoptosis in vascular dementia model rats.Molecular medicine reports · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Vascular cognitive impairment (VCI) is the second most common type of dementia that accounts for 15 to 30%. To date, VCI still lacks an effective therapeutic strategy and an objective diagnostic tool. MicroRNAs (miRNAs) are a class of small non-coding RNAs that control gene expression at the post-translational level, playing an essential role in the pathogenesis of VCI. Moreover, accumulating evidence has indicated that miRNAs could be used as therapeutic strategies and diagnostic biomarkers of diseases. In this review, we summarize various mechanisms of miRNA-based therapeutics and candidate miRNAs for clinical diagnosis in VCI. Results showed that miRNAs participate in VCI via different mechanisms, including neuronal death, inflammation, oxidative stress, blood-brain barrier permeability, and synaptic translation. Circulating miRNAs of VCI have been detected in serum, plasma, and cerebrospinal fluid with various diagnostic power. Taking together, miRNAs are a potential biomarker for being a therapeutic agent and a diagnostic tool of VCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.