ArticleThe American journal of emergency medicine2020
Dexmedetomidine and worsening hypoxemia in the setting of COVID-19: A case report.
Article in The American journal of emergency medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Dexmedetomidine for acute respiratory conditions requiring non-invasive respiratory support in pediatric and adult patients: systematic review and meta-analysis of the literature.Frontiers in medicine · 2026Pooled it
- Association between Dexmedetomidine Use and Mortality in Patients with COVID-19 Receiving Invasive Mechanical Ventilation: A U.S. National COVID Cohort Collaborative (N3C) Study.Journal of clinical medicine · 2024Article
- Sedation in mechanically ventilated covid-19 patients: A narrative review for emergency medicine providers.The American journal of emergency medicine · 2022Review
- Awake pronation with helmet continuous positive airway pressure for COVID-19 acute respiratory distress syndrome patients outside the ICU: A case series.Medicina intensiva · 2022Article
- Dexmedetomidine in COVID-19: probing promises with prudence!The American journal of emergency medicine · 2021Article
- Anaesthesia-related drugs and SARS-CoV-2 infection.British journal of anaesthesia · 2021Article
- Peptides-based vaccine against SARS-Bio-design and manufacturing · 2021Article
- The Association of an Alpha-2 Adrenergic Receptor Agonist and Mortality in Patients With COVID-19.Frontiers in medicine · 2021Article
- Dexmedetomidine: another arrow in the quiver to fight COVID-19 in intensive care units.British journal of anaesthesia · 2021Article
- Awake pronation with helmet continuous positive airway pressure for COVID-19 acute respiratory distress syndrome patients outside the ICU: A case series.Medicina intensiva · 2020Article
- Perioperative pain management in COVID-19 patients: Considerations and recommendations by the Saudi Anesthesia Society (SAS) and Saudi Society of Pain Medicine (SSPM).Saudi journal of anaesthesiaArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emergency department management of hypoxemia in the setting of COVID-19 is riddled with uncertainty. The lack of high-quality research has translated to an absence of clarity at the bedside. With disease spread outpacing treatment consensus, provider discretion has taken on a heightened role. Here, we report a case of dexmedetomidine use in the setting of worsening hypoxemia, whereby oxygenation improved and intubation was avoided. Well known pharmacologic properties of the drug, namely the lack of respiratory depression and its anti-delirium effects, as well as other possible physiologic effects, suggest potential benefit for patients being managed with a delayed intubation approach. If dexmedetomidine can improve compliance with non-invasive oxygen support (the current recommended first-line therapy) while promoting better oxygenation, it may also decrease the need for mechanical ventilation and thus improve mortality.
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