Evidence map›Paper›PMID 32475715›Full record

ArticleUltrasound in medicine & biology2020

Optimization of Ultrasound Backscatter Spectroscopy to Assess Neurotoxic Effects of Anesthesia in the Newborn Non-human Primate Brain.

Laura Castañeda-Martinez, Kevin K Noguchi, Chrysanthy Ikonomidou, James A Zagzebski, Timothy J Hall, Ivan M Rosado-Mendez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Laura Castañeda-MartinezInstituto de Fisica, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico.
Kevin K NoguchiDepartment of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, USA.
Chrysanthy IkonomidouDepartment of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
James A ZagzebskiDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Timothy J HallDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Ivan M Rosado-MendezInstituto de Fisica, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico; Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA. Electronic address: irosado@fisica.unam.mx.
University of Wisconsin–Madison · USUniversidad Nacional Autónoma de México · MXWashington University in St. Louis · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2015 to 2019
$7.1M
Monitoring Changes in Cervical Microstructure During PregnancyR01HD072077 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI FELTOVICH, HELEN, HALL, TIMOTHY J · 2013 to 2022
$6.1M
HYPOTHERMIA TO PREVENT NEUROTOXIC SIDE EFFECTS OF PEDIATRIC DRUGSR01HD083001 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI IKONOMIDOU, HRISSANTHI · 2016 to 2019
$2.1M
NICHD NIH HHS R01 HD072077NICHD NIH HHS R01 HD083001NICHD NIH HHS U54 HD087011NIH HHS P51 OD011106
6 · The paper itself

Abstract

Studies in animal models have revealed that long exposures to anesthetics can induce apoptosis in the newborn and young developing brain. These effects have not been confirmed in humans because of the lack of a non-invasive, practical in vivo imaging tool with the ability to detect these changes. Following the successful use of ultrasound backscatter spectroscopy (UBS) to monitor in vivo cell death in breast tumors, we aimed to use UBS to assess the neurotoxicity of the anesthetic sevoflurane (SEVO) in a non-human primate (NHP) model. Sixteen 2- to 7-day-old rhesus macaques were exposed for 5 h to SEVO. Ultrasound scanning was done with a phased array transducer on a clinical ultrasound scanner operated at 10 MHz. Data consisting of 10-15 frames of radiofrequency (RF) echo signals from coronal views of the thalamus were obtained 0.5 and 6.0 h after initiating exposure. The UBS parameter "effective scatterer size" (ESS) was estimated by fitting a scattering form factor (FF) model to the FF measured from RF echo signals. The approach involved analyzing the frequency dependence of the measured FF to characterize scattering sources and selecting the FF model based on a χ

Indexed as

AnestheticsAnimalsAnimals, NewbornApoptosisMacaca mulattaSevofluraneSpectrum AnalysisThalamusUltrasonographyAnestheticsSevofluraneApoptosisEffective scatterer sizeNewborn brainQuantitative ultrasoundSevofluraneThalamus

Identifiers

PMID32475715
PMCPMC8142938
OpenAlexW3031542180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.