Evidence map›Paper›PMID 32475350›Full record

SynthesisJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2020

Cardiac structural changes after transcatheter aortic valve replacement: systematic review and meta-analysis of cardiovascular magnetic resonance studies.

Ghazaleh Mehdipoor, Shmuel Chen, Saurav Chatterjee, Pooya Torkian, Ori Ben-Yehuda, Martin B Leon, Gregg W Stone, Martin R Prince

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Functional and structural reverse myocardial remodeling following transcatheter aortic valve replacement: a prospective cardiovascular magnetic resonance study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Trial
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  11. Observational
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  19. Hydraulic forces assist left ventricular filling in aortic stenosis at baseline and after valve replacement.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Ghazaleh MehdipoorCardiovascular Research Foundation, New York, NY, USA.
Shmuel ChenCardiovascular Research Foundation, New York, NY, USA.
Saurav ChatterjeeHoffman Heart Institute, Saint Francis Hospital of the University of Connecticut, Hartford, CT, USA.
Pooya TorkianShahid Beheshti University of Medical Sciences, Tehran, Iran.
Ori Ben-YehudaCardiovascular Research Foundation, New York, NY, USA.
Martin B LeonCardiovascular Research Foundation, New York, NY, USA.
Gregg W StoneCardiovascular Research Foundation, New York, NY, USA.
Martin R PrinceDepartment of Radiology, Weill Cornell Medical College& New York Presbyterian Hospital, 416 East 55th Street, New York, NY, 10022, USA. map2008@med.cornell.edu.
Cardiovascular Research Foundation · USColumbia University · USIcahn School of Medicine at Mount Sinai · USPresbyterian Hospital · USSaint Francis Hospital · USShahid Beheshti University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscatheter aortic valve replacement (TAVR) is increasingly used to treat patients with severe aortic stenosis (AS). Cardiovascular magnetic resonance imaging (CMR) provides reliable and reproducible estimates for assessment of cardiac structure and function after TAVR. The goal of this study was to conduct a systematic review and meta-analysis of the literature to assess left ventricular (LV) volumes, mass and function by CMR after TAVR.

methodsUsing Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines, we searched PubMed and Embase for studies reporting CMR findings before and at least 1 month after TAVR. Main factors of interest were LV end-diastolic volume index (LVEDVi), LV end-systolic volume index (LVESVi), LV mass index (LVMi), and left ventricular ejection fraction (LVEF). Standardized mean differences (SMD) were pooled by random effects meta-analytic techniques.

resultsOf 453 screened publications, 10 studies (published between 2012 and 2018) were included. A total of 305 patients completed pre- and post-TAVR follow-up CMR (mean age range 78.6-85.0 years, follow-up range 6-15 months). Random effects analysis showed TAVR resulted in reduced LVEDVi (SMD: -0.25, 95% CI: - 0.43 to - 0.07, P = 0.006), LVESVi (SMD: -0.24, 95% CI: - 0.44 to - 0.05, P = 0.01), LVMi (SMD: -0.82, 95% CI: - 1.0 to - 0.63, P < 0.001) and increased LVEF (SMD: 22, 95% CI: 6 to 38%, P = 0.006). Heterogeneity across studies was low (I

conclusionsCMR demonstrates reverse LV remodeling occurrs within 6-15 months after TAVR, with reductions in LVEDVi, LVESVi and LVMi, and increased LVEF.

Indexed as

Magnetic Resonance ImagingTranscatheter Aortic Valve ReplacementVentricular Function, LeftVentricular RemodelingAgedAged, 80 and overAortic ValveAortic Valve StenosisFemaleHeart VentriclesHumansMalePredictive Value of TestsRecovery of FunctionTime FactorsTreatment OutcomeAortic stenosisCardiac structureMagnetic resonance imaging (MRI)Transcatheter aortic valve implantation (TAVI)Transcatheter aortic valve replacement (TAVR)

Identifiers

PMID32475350
PMCPMC7262773
OpenAlexW3030867362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.