Evidence map›Paper›PMID 32475319›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Evidence for a Physiological Mitochondrial Angiotensin II System in the Kidney Proximal Tubules: Novel Roles of Mitochondrial Ang II/AT

Xiao Chun Li, Xinchun Zhou, Jia Long Zhuo

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. The relationship between estrogen and renin angiotensin system components in the context of hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Angiotensin II and ATInternational journal of molecular sciences · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Vascular Stress Signaling in Hypertension.Circulation research · 2021
    Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Xiao Chun LiFrom the Tulane Hypertension and Renal Center of Excellence (X.C.L., J.L.Z.), Tulane University School of Medicine, New Orleans, LA.
Xinchun ZhouDepartment of Pathology (X.Z.), University of Mississippi Medical Center, Jackson.
Jia Long ZhuoFrom the Tulane Hypertension and Renal Center of Excellence (X.C.L., J.L.Z.), Tulane University School of Medicine, New Orleans, LA.
Tulane University · USUniversity of Mississippi Medical Center · US

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Babbette LaMarca, Jane F Reckelhoff · 2017 to 2026
$26.4M
Role of Intracrine Angiotensin II in Kidney CellsR01DK067299 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jia Long Zhuo · 2004 to 2026
$6.5M
Role of Proximal Tubule NHE3 in Angiotensin II-induced HypertensionR01DK102429 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHUO, JIA LONG · 2014 to 2021
$2.5M
Intratubular Angiotensin II and AT1a Receptors in The Proximal Tubules: Roles in Hypertension and Kidney InjuryR01DK123144 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI ZHUO, JIA LONG · 2020 to 2023
$1.8M
The Na+/H+ Exchanger 3, Pressure Natriuresis, and HypertensionR56HL130988 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHUO, JIA LONG · 2016 to 2016
$381k
Novel Roles of Intracrine Angiotensin II in Proximal Tubule CellsR56DK067299 · NIDDK · HENRY FORD HEALTH SYSTEM · PI ZHUO, JIA LONG · 2009 to 2009
$352k
NHLBI NIH HHS R56 HL130988NIDDK NIH HHS R01 DK067299NIDDK NIH HHS R01 DK102429NIDDK NIH HHS R01 DK123144NIDDK NIH HHS R56 DK067299NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

The present study tested the hypotheses that overexpression of an intracellular Ang II (angiotensin II) fusion protein, mito-ECFP/Ang II, selectively in the mitochondria of mouse proximal tubule cells induces mitochondrial oxidative and glycolytic responses and elevates blood pressure via the Ang II/AT

Indexed as

Angiotensin IIAngiotensin II Type 2 Receptor BlockersAnimalsCells, CulturedGlycolysisHypertensionImidazolesKidney CortexKidney Tubules, ProximalMaleMiceMice, Inbred C57BLMitochondriaNG-Nitroarginine Methyl EsterOrganophosphorus CompoundsPiperidinesAngiotensin IIAngiotensin II Type 2 Receptor BlockersImidazolesMitoTEMPONG-Nitroarginine Methyl EsterOrganophosphorus CompoundsPD 123319PiperidinesPyridinesReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Slc4a4 protein, mouseSlc9a1 protein, mouseSodiumSodium-Bicarbonate SymportersSodium-Hydrogen Exchanger 1Sodium-Potassium-Exchanging ATPaseangiotensin IIblood pressurehomeostasismitochondriasuperoxides

Identifiers

PMID32475319
PMCPMC7299167
OpenAlexW3029782024

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.