Evidence map›Paper›PMID 32475313›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

NOX4/H

Vikash Kumar, Theresa Kurth, Nadezhda N Zheleznova, Chun Yang, Allen W Cowley

Open access · greenAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Aging-AssociatedJournal of the American Heart Association · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Reactive oxygen species in hypertension.Nature reviews. Cardiology · 2025
    Review
  10. Oxidative Stress in Kidney Injury and Hypertension.Antioxidants (Basel, Switzerland) · 2024
    Review
  11. Article
  12. Oxidative Stress, Antioxidants and Hypertension.Antioxidants (Basel, Switzerland) · 2023
    Review
  13. Article
  14. Cells · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Potential Therapeutic Effects ofPharmaceuticals (Basel, Switzerland) · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Vikash KumarFrom the Department of Physiology, Medical College of Wisconsin, Milwaukee.
Theresa KurthFrom the Department of Physiology, Medical College of Wisconsin, Milwaukee.
Nadezhda N ZheleznovaFrom the Department of Physiology, Medical College of Wisconsin, Milwaukee.
Chun YangFrom the Department of Physiology, Medical College of Wisconsin, Milwaukee.
Allen W CowleyFrom the Department of Physiology, Medical College of Wisconsin, Milwaukee.
Medical College of Wisconsin · US

Funding

Therapeutic Effects of mTOR Inhibition in Salt-Sensitive HypertensionP01HL116264 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MATTSON, DAVID L. · 2013 to 2021
$18.7M
Mechanisms of renal immune cell infiltration in salt-sensitive hypertensionR01HL137748 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI COWLEY, ALLEN W, MATTSON, DAVID L. · 2018 to 2021
$2.3M
NHLBI NIH HHS P01 HL116264NHLBI NIH HHS R01 HL137748
6 · The paper itself

Abstract

We have reported that a high-salt (4.0% NaCl) dietary intake activates mTORC1 and inhibition of this pathway with rapamycin blunts the chronic phase of salt-induced hypertension and renal injury in Dahl salt-sensitive (SS) rats. In SS rats, high-salt intake is known to increase the renal production of H

Indexed as

Adenylate KinaseAnimalsCell LineChromonesHydrogen PeroxideHypertensionKidneyKidney DiseasesMaleMechanistic Target of Rapamycin Complex 1MorpholinesNADPH Oxidase 4Phosphatidylinositol 3-KinasesPhosphorylationProtein Processing, Post-TranslationalProto-Oncogene Proteins c-aktAdenylate KinaseAkt1 protein, ratChromonesHydrogen PeroxideLY 290042Mechanistic Target of Rapamycin Complex 1MorpholinesNADPH Oxidase 4Nox4 protein, ratPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSirolimusSodium Chloride, Dietaryamino acidglucoseinsulinrapamycinreactive oxygen species

Identifiers

PMID32475313
PMCPMC10629473
OpenAlexW3028997475

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.