Evidence map›Paper›PMID 32474810›Full record

SynthesisClinical oral investigations2020

Periodontal disease and Helicobacter pylori infection in oral cavity: a meta-analysis of 2727 participants mainly based on Asian studies.

Yanqing Liu, Rong Li, Xiaomeng Xue, Tong Xu, Yuxiao Luo, Qin Dong, Junchao Liu, Jingbo Liu, Yaping Pan, Dongmei Zhang

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Nutrients · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Relationship betweenWorld journal of gastrointestinal surgery · 2024
    Article
  8. Review
  9. Article
  10. Controlling the Impact ofMedicina (Kaunas, Lithuania) · 2023
    Article
  11. International journal of molecular sciences · 2022
    Review
  12. Article
  13. Oral and Fecal Microbiome in Molar-Incisor Pattern Periodontitis.Frontiers in cellular and infection microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yanqing LiuDepartment of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China.
Rong LiDepartment of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China.
Xiaomeng XueDepartment of Oromaxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China.
Tong XuDepartment of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China.
Yuxiao LuoDepartment of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China.
Qin DongDepartment of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China.
Junchao LiuDepartment of Periodontics and Oral Biology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping Distrct, Nanjing North Street No.117, Shenyang, 110002, China.
Jingbo LiuDepartment of Periodontics and Oral Biology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping Distrct, Nanjing North Street No.117, Shenyang, 110002, China.
Yaping PanDepartment of Periodontics and Oral Biology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping Distrct, Nanjing North Street No.117, Shenyang, 110002, China.
Dongmei ZhangDepartment of Periodontics and Oral Biology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping Distrct, Nanjing North Street No.117, Shenyang, 110002, China. zhangdongmei@cmu.edu.cn.ORCID http://orcid.org/0000-0001-6180-0253
China Medical University · CN

Funding

Natural Science Foundation of Liaoning Province 201800506
6 · The paper itself

Abstract

objectivesTo assess the association between periodontal disease and Helicobacter pylori (H. pylori) infection in oral cavity. MATERIALS AND

methodsWe searched PubMed, Embase, Web of Science, Cochrane library, Gray literature, and clinicaltrials.gov for eligible studies up to September 25, 2019. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The random-effects model was used with the software STATA 13.0. The Newcastle-Ottawa-Scale was used for quality evaluation.

resultsTwelve observational studies (eight from Asia, one from Europe, and three from the South America) involving 2727 participants were included in the meta-analysis. The overall pooled results showed that H. pylori infection in oral cavity was associated with periodontal disease (OR 2.53, 95% CI 1.86-3.44, P < 0.05). No significant heterogeneity among the articles was observed (I

conclusionsBased on current available evidence, it seemed there was a correlation between oral H. pylori infection and the occurrence of periodontal disease. However, since most of the data comes from Asia, more large-scale investigations with high quality from all over the world are needed to confirm the association. CLINICAL RELEVANCE: H. pylori infection in oral may have a positive association with the prevalence of periodontal disease mainly in Asian populations.

Indexed as

Helicobacter InfectionsHelicobacter pyloriPeriodontal DiseasesAsiaEuropeHumansHelicobacter pyloriMeta-analysisOral cavityPeriodontal disease

Identifiers

PMID32474810
OpenAlexW3030975008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.