ReviewHeart failure reviews2021
Clinical inertia in the treatment of heart failure: a major issue to tackle.
Review in Heart failure reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07252310 (Pilot Study of Acceptability and Feasibility of StudyU for N-of-1 Trials), which is not on this map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study of Acceptability and Feasibility of StudyU for N-of-1 Trials
Who cites it
46 citing papers in PubMed, 104 citations in OpenAlex.
- Primary care Adherence to Heart failure guidelines in post-discharge, evaluation & routine management (PATHFINDER): a randomized controlled trial.ESC heart failure · 2026Trial
- Discharge neutrophily-to-lymphocyte ratio and its trajectory as predictors of 30-day outcomes in acute heart failure.ESC heart failure · 2026Article
- Article
- Heart Failure and Comorbidities (Chronic Kidney Disease, Diabetes, Obesity) Management: A Multidisciplinary Approach.Cardiorenal medicine · 2026Review
- Prevention and Management of Heart Failure Associated with Type 2 Diabetics in Rural Australia.Journal of clinical medicine · 2025Review
- Optimization of renin-angiotensin-aldosterone inhibitor therapies for evidence-based indications: A call to action from the cardio-kidney community.American journal of preventive cardiology · 2025Article
- Article
- Optimization of renin-angiotensin-aldosterone inhibitor therapies for evidence-based indications: a call to action from the cardio-kidney community.ESC heart failure · 2025Article
- Optimization of Renin-Angiotensin-Aldosterone Inhibitor Therapies for Evidence-Based Indications: a Call to Action From the Cardio-Kidney Community.Kidney international reports · 2025Article
- Utilization and dose optimization of beta-blockers in chronic heart failure therapy: a mixed-methods study.BMC cardiovascular disorders · 2025Article
- Is It Safe to Initiate/Optimize the Medication of HFrEF Patients During Hospitalization for Acute Decompensation?Journal of clinical medicine · 2025Article
- Lower albumin levels are associated with 1-year mortality in older patients hospitalized for acute heart failure: THE ALBIMED-HF study.Internal and emergency medicine · 2025Article
- Evaluating the Relationship Between Inertia Levels and Tendency to Medical Errors Among Nurses in Paediatric Clinics.Journal of evaluation in clinical practice · 2025Article
- Automated Detection of Reduced Ejection Fraction Using an ECG-Enabled Digital Stethoscope: A Large Cohort Validation.JACC. Advances · 2025Article
- Quality of Care among Post-discharge Patients with Heart Failure with Reduced Ejection Fraction (HFrEF) at the Outpatient Department (OPD) of a Tertiary Center.Acta medica Philippina · 2025Article
- Improving Medication Adherence in Heart Failure Through Pharmacist-Led Patient Education: Protocol for a Mechanism-Based Study of Information, Motivation, and Behavioral Skills.Patient preference and adherence · 2025Article
- Treatment Inertia Among Elderly Patients with Chronic Heart Failure: A Qualitative Study.Patient preference and adherence · 2025Article
- Article
- Patterns of use and dose optimization of renin-angiotensin system modulators among chronic heart failure patients with reduced ejection fraction in resource-limited settings: a multicenter cohort study.Therapeutic advances in chronic disease · 2025Article
- Improving the Management of Patients with Heart Failure with Reduced Ejection Fraction in Clinical Practice: The Case for Angiotensin Receptor-Neprilysin Inhibitor.Cardiac failure review · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite an enormous improvement in heart failure management during the last decades, the hospitalization and mortality rate of heart failure patients still remain very high. Clinical inertia, defined as the lack of treatment intensification in a patient not at evidence-based goals for care, is an important underlying cause. Clinical inertia is extensively described in hypertension and type 2 diabetes mellitus, but increasingly recognized in heart failure as well. Given the well-established guidelines for the management of heart failure, these are still not being reflected in clinical practice. While the absolute majority of patients were treated by guideline-directed heart failure drugs, only a small percentage of these patients reached the correct guideline-recommended target dose of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, mineralocorticoid receptor antagonists, and angiotensin receptor-neprilysin inhibitors. This considerable under-treatment leads to a large number of avoidable hospitalizations and deaths. This review discusses clinical inertia in heart failure and explains its major contributing factors (i.e., physician, patient, and system) and touches upon some recommendations to prevent clinical inertia and ameliorate heart failure treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.