ArticleDigestive diseases and sciences2021
Experience with Esophageal Granular Cell Tumors: Clinical and Endoscopic Analysis of 22 Cases.
Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 19 citations in OpenAlex.
- Esophageal Granular Cell Tumor Associated With Eosinophilic Gastrointestinal Disease.ACG case reports journal · 2025Article
- Endoscopic resection for esophageal granular cell tumors: report of 62 cases.BMC gastroenterology · 2024Article
- Successful endoscopic submucosal dissection of an esophageal granular cell tumor in a pediatric patient: A case report and a therapeutic insight.JPGN reports · 2024Article
- Clinical outcomes of esophageal granular cell tumors with different endoscopic resection methods.Scientific reports · 2023Article
- A case of esophageal granular cell tumor diagnosed by mucosal incision-assisted biopsy.Clinical journal of gastroenterology · 2022Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEsophageal granular cell tumors (GCTs) are rare tumors. Differences in reports on the clinical features of GCTs in the esophagus and some controversies about the diagnostic strategy for esophageal GCTs exist.
objectivesWe aimed to investigate the clinical features and diagnosis of esophageal GCTs. Additionally, we sought to determine the prevalence of gastroesophageal reflux disease and reflux esophagitis in patients with esophageal GCTs.
methodsWe retrospectively studied the clinical features, endoscopic features, and management of 22 patients with esophageal GCTs.
resultsEsophageal GCTs were more common in men than in women with a ratio of 1.2:1 and were predominantly found in the distal esophagus. Ten patients with esophageal GCTs had regurgitation and/or heartburn symptoms, and eight patients were confirmed to have reflux esophagitis by endoscopy. All esophageal GCTs were protuberant lesions covered by normal esophageal epithelium. The endoscopic morphology of esophageal GCTs was diverse. On endoscopic ultrasonography, these tumors appeared as homogeneous or inhomogeneous hypoechoic lesions with clear borders originating from the submucosal or mucosal layer. Eleven patients underwent endoscopic forceps biopsy at the first endoscopy, and only six patients were correctly diagnosed by pathology. Nevertheless, the 18 lesions treated with endoscopic resection were all correctly diagnosed without complications, and no patients developed recurrence during the follow-up period.
conclusionsThe occurrence of esophageal GCTs may be related to esophageal inflammation. As a method for obtaining an accurate pathological diagnosis and for treatment, endoscopic resection should be offered as the primary option for patients with esophageal GCTs.
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