Evidence map›Paper›PMID 32474761›Full record

ArticleJournal of cardiovascular translational research2021

Targeting the MicroRNA-490-3p-ATG4B-Autophagy Axis Relieves Myocardial Injury in Ischemia Reperfusion.

Yufu Wu, Qing Mao, Xiulin Liang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Yufu WuDepartment of Cardiology, Liuzhou Traditional Chinese Medical Hospita, The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou, 545001, People's Republic of China.
Qing MaoDepartment of Cardiology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, No. 86, Chongwen Road, Lishui District, Nanjing, 211200, Jiangsu, People's Republic of China. maoqing8@yeah.net.
Xiulin LiangDepartment of Neurology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, People's Republic of China.
Guangxi Medical University · CNGuangxi University of Chinese Medicine · CNLishui City People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the potential role of miR-490-3p in ischemia reperfusion (IR) injury. We first determined the expression of miR-490-3p and autophagy-related 4B cysteine (ATG4B) in IR. Then, to explore whether miR-490-3p would affect autophagy, apoptosis, and IR injury, we evaluated apoptosis, autophagy, and infarct size via gain- and loss-of-function experiments. Furthermore, we used adenovirus to enhance or inhibit the expression of ATG4B, and then measured autophagy, apoptosis, and IR injury. miR-490-3p was downregulated in the hearts during the process of IR, while ATG4B was upregulated. The inhibition of miR-490-3p or overexpression of ATG4B could promote the expression of LC3II, increase the autolysosomes, inhibit the expression of p62, and reduce infarct size. On all accounts, the inhibition of miR-490-3p could promote autophagy to reduce myocardial IR injury by upregulating ATG4B, a finding that provides new insights for the protective mechanism of autophagy in IR. Graphical Abstract.

Indexed as

Gene Expression RegulationAnimalsApoptosisAutophagyAutophagy-Related ProteinsCysteine EndopeptidasesDisease Models, AnimalMiceMicroRNAsMyocardial Reperfusion InjuryMyocytes, CardiacRNAAtg4b protein, mouseAutophagy-Related ProteinsCysteine EndopeptidasesMicroRNAsMIRN490 microRNA, mouseRNAApoptosisAutophagyAutophagy-related 4B cysteineIschemia reperfusionmicroRNA-490-3p

Identifiers

PMID32474761
OpenAlexW3032814461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.