Evidence map›Paper›PMID 32474754›Full record

ArticleBrain structure & function2020

Hemodynamic latency is associated with reduced intelligence across the lifespan: an fMRI DCM study of aging, cerebrovascular integrity, and cognitive ability.

Ariana E Anderson, Mirella Diaz-Santos, Spencer Frei, Bianca H Dang, Pashmeen Kaur, Patrick Lyden, Richard Buxton, Pamela K Douglas, Robert M Bilder, Mahtash Esfandiari and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain structure & function, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Revealing the Spatial Pattern of Brain Hemodynamic Sensitivity to Healthy Aging through Sparse Dynamic Causal Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  2. Article
  3. Article
  4. DCE-MRI of Brain Fluid Barriers:Tissue barriers · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Ariana E AndersonDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plaza, Suite 28-224, Los Angeles, 90095, USA. arianaanderson@mednet.ucla.edu.ORCID http://orcid.org/0000-0003-2207-5284
Mirella Diaz-SantosDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plaza, Suite 28-224, Los Angeles, 90095, USA.
Spencer FreiDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plaza, Suite 28-224, Los Angeles, 90095, USA.
Bianca H DangDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plaza, Suite 28-224, Los Angeles, 90095, USA.
Pashmeen KaurDepartment of Statistics, University of California, Los Angeles, USA.
Patrick LydenDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Richard BuxtonDepartment of Radiology, University of California, San Diego, USA.
Pamela K DouglasDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plaza, Suite 28-224, Los Angeles, 90095, USA.
Robert M BilderDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plaza, Suite 28-224, Los Angeles, 90095, USA.
Mahtash EsfandiariDepartment of Statistics, University of California, Los Angeles, USA.
Karl J FristonInstitute of Neurology, University College London, London, UK.
Usha NookalaDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plaza, Suite 28-224, Los Angeles, 90095, USA.
Susan Y BookheimerDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plaza, Suite 28-224, Los Angeles, 90095, USA.
Neurobehavioral Systems · USUniversity of California, Los Angeles · USCedars-Sinai Medical Center · USUniversity College London · GBUniversity of California San Diego · USUniversity of Central Florida · US

Funding

MAPPING THE HUMAN CONNECTOME DURING TYPICAL AGINGU01AG052564 · NIA · WASHINGTON UNIVERSITY · PI SALAT, DAVID H, TERPSTRA, MELISSA J · 2016 to 2020
$18.9M
ZZ-3K3A-201: Safety evaluation of 3K3A-APC in ischemic strokeU01NS088312 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI LYDEN, PATRICK D · 2014 to 2017
$7.4M
Human Translational Applications Core (HTA - Core) (7 of 8)PL1MH083271 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2007 to 2011
$5.8M
Thrombin Mediated Cytotoxicity during Cerebral IschemiaR01NS075930 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LYDEN, PATRICK D · 2011 to 2020
$3.6M
Multi-Level Assays of Working Memory and PsychopathologyR01MH101478 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2014 to 2018
$3.0M
Consortium for Neuropsychiatric Phenomics-Coordinating Center (1 of 8)UL1DE019580 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2008 to 2011
$1.9M
Hemodynamic Biomarkers of Healthy and Diseased AgingK25AG051782 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANDERSON, ARIANA · 2016 to 2020
$667k
Structural and Functional Biomarkers of Attention-Deficit/Hyperactivity DisorderK01MH110645 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DOUGLAS, PK · 2017 to 2020
$632k
Modeling RDoc Dimensions Across Levels of AnalysisR03MH106922 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANDERSON, ARIANA · 2016 to 2017
$154k
Burroughs Wellcome Fund CASINational Institute on Aging (US) AG052564-01NIA NIH HHS K25 AG051782NIA NIH HHS K25AG051782NIA NIH HHS U01 AG052564NIDCR NIH HHS UL1 DE019580NIMH NIH HHS K01 MH110645NIMH NIH HHS PL1 MH083271NIMH NIH HHS PL1MH083271NIMH NIH HHS R01 MH101478NIMH NIH HHS R01MH101478NIMH NIH HHS R03 MH106922NIMH NIH HHS R03MH106922NIMH NIH HHS UL1DE019580NINDS NIH HHS R01 NS075930NINDS NIH HHS R01NS075930NINDS NIH HHS U01 NS088312
6 · The paper itself

Abstract

Changes in neurovascular coupling are associated with both Alzheimer's disease and vascular dementia in later life, but this may be confounded by cerebrovascular risk. We hypothesized that hemodynamic latency would be associated with reduced cognitive functioning across the lifespan, holding constant demographic and cerebrovascular risk. In 387 adults aged 18-85 (mean = 48.82), dynamic causal modeling was used to estimate the hemodynamic response function in the left and right V1 and V3-ventral regions of the visual cortex in response to a simple checkerboard block design stimulus with minimal cognitive demands. The hemodynamic latency (transit time) in the visual cortex was used to predict general cognitive ability (Full-Scale IQ), controlling for demographic variables (age, race, education, socioeconomic status) and cerebrovascular risk factors (hypertension, alcohol use, smoking, high cholesterol, BMI, type 2 diabetes, cardiac disorders). Increased hemodynamic latency in the visual cortex predicted reduced cognitive function (p < 0.05), holding constant demographic and cerebrovascular risk. Increased alcohol use was associated with reduced overall cognitive function (Full Scale IQ 2.8 pts, p < 0.05), while cardiac disorders (Full Scale IQ 3.3 IQ pts; p < 0.05), high cholesterol (Full Scale IQ 3.9 pts; p < 0.05), and years of education (2 IQ pts/year; p < 0.001) were associated with higher general cognitive ability. Increased hemodynamic latency was associated with reduced executive functioning (p < 0.05) as well as reductions in verbal concept formation (p < 0.05) and the ability to synthesize and analyze abstract visual information (p < 0.01). Hemodynamic latency is associated with reduced cognitive ability across the lifespan, independently of other demographic and cerebrovascular risk factors. Vascular health may predict cognitive ability long before the onset of dementias.

Indexed as

HemodynamicsAdolescentAdultAgedAged, 80 and overAgingBrainBrain MappingCerebrovascular DisordersHumansIntelligenceLongevityMagnetic Resonance ImagingMiddle AgedRisk FactorsYoung AdultCerebrovascularCognitionDynamic causal modelingfMRIHemodynamic response functionVascular dementia

Identifiers

PMID32474754
PMCPMC9254437
OpenAlexW3032055621

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.