Trial reportEuropean journal of applied physiology2020
The use of whole-body cryotherapy: time- and dose-response investigation on circulating blood catecholamines and heart rate variability.
Trial report in European journal of applied physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- Repeated whole-body cryostimulation promotes a blood pressure reduction at rest in healthy adult men.European journal of applied physiology · 2026Trial
- Effects of Whole-Body Cryotherapy Combined With Conventional Obesity Management Versus Obesity Management Alone: A Clinical Trial.Obesity (Silver Spring, Md.) · 2025Trial
- Cryo-Induced Hypoalgesia: The Effects of an Acute Cryochamber Exposure on Pain Perception-A Randomised Controlled Cross-Over Trial.European journal of pain (London, England) · 2025Trial
- The effectiveness of cryostimulation exposure on sleep and recovery in male athletes: Timing considerations.European journal of sport science · 2024Trial
- Optimal duration of whole-body cryostimulation exposure to achieve target skin temperature: influence of body mass index-a randomized cross-over controlled trial.Journal of physiological anthropology · 2024Trial
- The effectiveness of the Wim Hof method on cardiac autonomic function, blood pressure, arterial compliance, and different psychological parameters.Scientific reports · 2023Trial
- Impact of acute partial-body cryostimulation on cognitive performance, cerebral oxygenation, and cardiac autonomic activity.Scientific reports · 2021Trial
- Cardiovascular Autonomic Dysfunction in Cancer Therapy: Clinical Manifestations and Management.Cardiology research · 2026Review
- Whole-Body Cryostimulation in Complex Regional Pain Syndrome: A Case Study.Journal of clinical medicine · 2026Article
- Effects of Whole-Body Cryostimulation on Stress Biomarkers and Psychological Well-Being in Parkinson's Disease: A Pilot Study.Journal of clinical medicine · 2026Article
- Thermal stress: an untapped potential in rehabilitation? An opinion paper on Finnish sauna and whole-body cryostimulation.Frontiers in rehabilitation sciences · 2026Review
- Effects of repeated cryostimulation exposures on sleep quality in swimmers during an intense training period.Experimental physiology · 2025Article
- Enhancing Cardiovascular Autonomic Regulation in Parkinson's Disease Through Non-Invasive Interventions.Life (Basel, Switzerland) · 2025Review
- Whole-body cryostimulation exposures effectively alleviates menstrual-related pain and associated sleep disturbances in young women: a randomized controlled trial.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Whole-Body Cold Stimulation Improves Cardiac Autonomic Control Independently of the Employed Temperature.Journal of clinical medicine · 2024Article
- Autonomic Modulation in Parkinson's Disease Using Whole-Body Cryostimulation: A Pilot Study.Biomedicines · 2024Article
- Impact of baseline arterial elasticity (stiffness) on left ventricular functions in healthy subjects exposed to short-term extreme cold.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Tackling Kinesiophobia in Chronic Shoulder Pain: A Case Report on the Combined Effect of Pain Education and Whole-Body Cryostimulation.Journal of clinical medicine · 2024Article
- Targeting Vascular Impairment, Neuroinflammation, and Oxidative Stress Dynamics with Whole-Body Cryotherapy in Multiple Sclerosis Treatment.International journal of molecular sciences · 2024Review
- Whole Body Cryostimulation: A New Adjuvant Treatment in Central Sensitization Syndromes? An Expert Opinion.Healthcare (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA predominance of parasympathetic drive is observed following cold exposure. Such modulation of the autonomic nervous system (ANS) is associated with faster post-exercise recovery. Within this context, whole-body cryotherapy (WBC) has been spreading in sport medicine, though the optimal temperature and frequency are unclear. The aim of this study was to examine the effects of different cryotherapy conditions on the sympathovagal balance.
methodsForty healthy males were randomly assigned into five different groups (- 110 °C, - 60 °C, - 10 °C, control temperature [≃ 24 °C]) and undertook 5 WBC sessions over 5 consecutive days. Cardiac autonomic activity was assessed through heart rate variability (HRV) using power density of high frequency (HF), root-mean square difference of successive R-R intervals (RMSSD) and sympathovagal balance (LF/HF). Systemic sympathetic activity was assessed via circulating blood catecholamines.
resultsMean weekly RMSSD (pre: 48 ± 22 ms, post: 68 ± 29 ms) and HF (pre: 607 ± 692 ms
conclusionThese results suggest that one - 110 °C WBC exposure is required to stimulate the ANS. After five daily exposures, a lower autonomic response was recorded compared to day one, therefore suggesting the development of physiological habituation to WBC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.