ArticleTranslational psychiatry2020
The intergenerational transmission of suicidal behavior: an offspring of siblings study.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Parental characteristics and offspring mental health and related outcomes: a systematic review of genetically informative literature.Translational psychiatry · 2021Pooled it
- A systematic review of controlled studies of suicidal and self-harming behaviours in adolescents following bereavement by suicide.PloS one · 2021Pooled it
- Developmental predictors of suicide attempts from childhood to early adulthood: a 15-year prospective cohort study.Lancet regional health. Americas · 2026Article
- Parental violent offending and offspring suicidal behavior: a nationwide register-based study.Psychological medicine · 2026Article
- Biological Risk Factors for Suicidal Behavior in Children and Adolescents: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Digitalized suicide risk assessment in emergency psychiatry services.Frontiers in psychiatry · 2026Article
- Exploring risk signals of association between drugs and suicide: a retrospective investigation from 2004 to 2024.Frontiers in psychiatry · 2026Article
- Forced marriage, domestic violence, and suicidal ideation among married individuals: a population-based study from Western Iran.BMC public health · 2025Article
- Work absence in parents of youth who self-harm.BMJ mental health · 2025Article
- Parental Mental Health and Suicidal Behavior as Predictors of Adolescent Suicidal Ideation and Attempts: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Parental Diseases of Despair and Suicidal Events in Their Children.JAMA network open · 2025Article
- Epigenetics and suicidal behavior in adolescents: a critical review.Epigenomics · 2025Review
- Article
- Maternal suicide risk predicts preschooler emotional and behavioral problems.Psychiatry research · 2024Article
- A Cross-Sectional Analysis of Parental Behavior and Adolescent Mental Health in Mexico: Insights into Excessive Alcohol Intake, Tobacco Use, Suicidal Behavior, and Depressive Symptomatology.Healthcare (Basel, Switzerland) · 2024Article
- Brain structural and functional signatures of multi-generational family history of suicidal behaviors in preadolescent children.Molecular psychiatry · 2024Article
- Suicidal Ideation in Iraqi Medical Students Based on Research Using PHQ-9 and SSI-C.International journal of environmental research and public health · 2023Article
- Genetic Association of Attention-Deficit/Hyperactivity Disorder and Major Depression With Suicidal Ideation and Attempts in Children: The Adolescent Brain Cognitive Development Study.Biological psychiatry · 2022Article
- Extended familial risk of suicide death is associated with younger age at death and elevated polygenic risk of suicide.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022Article
- Parenting in the Context of the Child: Genetic and Social Processes.Monographs of the Society for Research in Child Development · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
We examined the extent to which genetic factors shared across generations, measured covariates, and environmental factors associated with parental suicidal behavior (suicide attempt or suicide) account for the association between parental and offspring suicidal behavior. We used a Swedish cohort of 2,762,883 offspring born 1973-2001. We conducted two sets of analyses with offspring of half- and full-siblings: (1) quantitative behavior genetic models analyzing maternal suicidal behavior and (2) fixed-effects Cox proportional hazard models analyzing maternal and paternal suicidal behavior. The analyses also adjusted for numerous measured covariates (e.g., parental severe mental illness). Quantitative behavior genetic analyses found that 29.2% (95% confidence interval [CI], 5.29, 53.12%) of the intergenerational association was due to environmental factors associated with exposure to maternal suicidal behavior, with the remainder due to genetic factors. Statistical adjustment for parental behavioral health problems partially attenuated the environmental association; however, the results were no longer statistically significant. Cox hazard models similarly found that offspring were at a 2.74-fold increased risk [95% CI, 2.67, 2.83]) of suicidal behavior if their mothers attempted/died by suicide. After adjustment for familial factors and measured covariates, associations attenuated but remained elevated for offspring of discordant half-siblings (HR, 1.57 [95% CI, 1.45, 1.71]) and full-siblings (HR, 1.62 [95% CI, 1.57, 1.67]). Cox hazard models demonstrated a similar pattern between paternal and offspring suicidal behavior. This study found that the intergenerational transmission of suicidal behavior is largely due to shared genetic factors, as well as factors associated with parental behavioral health problems and environmental factors associated with parental suicidal behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.