Evidence map›Paper›PMID 32474445›Full record

ReviewMolecular pharmacology2020

Regulators of G Protein Signaling in Analgesia and Addiction.

Farhana Sakloth, Claire Polizu, Feodora Bertherat, Venetia Zachariou

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
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  5. Review
  6. Effects of positive mGlu5 modulation on DJournal of psychopharmacology (Oxford, England) · 2025
    Article
  7. Review
  8. Genetic mouse models in opioid research: current status and future directions.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
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  17. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Farhana SaklothNash Family Department of Neuroscience, and Friedman Brain Institute (F.S., C.P., F.B., V.Z.) and Department of Pharmacological Sciences (V.Z.), Icahn School of Medicine at Mount Sinai, New York, New York.
Claire PolizuNash Family Department of Neuroscience, and Friedman Brain Institute (F.S., C.P., F.B., V.Z.) and Department of Pharmacological Sciences (V.Z.), Icahn School of Medicine at Mount Sinai, New York, New York.
Feodora BertheratNash Family Department of Neuroscience, and Friedman Brain Institute (F.S., C.P., F.B., V.Z.) and Department of Pharmacological Sciences (V.Z.), Icahn School of Medicine at Mount Sinai, New York, New York.
Venetia ZachariouNash Family Department of Neuroscience, and Friedman Brain Institute (F.S., C.P., F.B., V.Z.) and Department of Pharmacological Sciences (V.Z.), Icahn School of Medicine at Mount Sinai, New York, New York venetia.zachariou@mssm.edu.
Allen Institute for Brain Science · USIcahn School of Medicine at Mount Sinai · US

Funding

TRANSGENIC COREP01DA008227 · NIDA · YALE UNIVERSITY · PI NESTLER, ERIC J. · 1993 to 2018
$28.1M
Transcription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI YASMIN L. HURD · 2019 to 2026
$16.5M
Cellular Mechanisms of Antidepressant Drug Actions in Neuropathic Pain ModelsR01NS086444 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZACHARIOU, VENETIA · 2014 to 2023
$4.4M
A Female Specific Role of RGSz1 in Modulation of Chronic PainR01NS111351 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZACHARIOU, VENETIA · 2020 to 2024
$1.9M
A Female Specific Role of RGSz1 in Modulation of Chronic PainR56NS111351 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZACHARIOU, VENETIA · 2019 to 2019
$517k
NIDA NIH HHS P01 DA008227NIDA NIH HHS P01 DA047233NINDS NIH HHS R01 NS086444NINDS NIH HHS R01 NS111351NINDS NIH HHS R56 NS111351
6 · The paper itself

Abstract

Regulator of G protein signaling (RGS) proteins are multifunctional proteins expressed in peripheral and neuronal cells, playing critical roles in development, physiologic processes, and pharmacological responses. RGS proteins primarily act as GTPase accelerators for activated G

Indexed as

AnalgesiaAnalgesics, OpioidAnimalsBrainDisease Models, AnimalDopamineDrug ToleranceGTP-Binding ProteinsHumansNeuronal PlasticityNeuronsNociceptionPsychotropic DrugsRGS ProteinsSignal TransductionSubstance-Related DisordersAnalgesics, OpioidDopamineGTP-Binding ProteinsPsychotropic DrugsRGS Proteins

Identifiers

PMID32474445
PMCPMC7662521
OpenAlexW3030155603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.