Evidence map›Paper›PMID 32474310›Full record

ArticleEnvironmental research2020

Prediagnostic serum polychlorinated biphenyl concentrations and primary liver cancer: A case-control study nested within two prospective cohorts.

Nicole M Niehoff, Emily C Zabor, Jaya Satagopan, Anders Widell, Thomas R O'Brien, Mingdong Zhang, Nathaniel Rothman, Tom K Grimsrud, Stephen K Van Den Eeden, Lawrence S Engel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Nicole M NiehoffEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Emily C ZaborDepartment of Quantitative Health Sciences, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Jaya SatagopanDepartment of Biostatistics and Epidemiology, School of Public Health, Rutgers- the State University of New Jersey, Piscataway, NJ, USA.
Anders WidellDepartment of Medical Microbiology, Lund University, Malmö, Sweden.
Thomas R O'BrienDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, MD, USA.
Mingdong ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, MD, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, MD, USA.
Tom K GrimsrudDepartment of Research, Cancer Registry of Norway, Institute of Population-based Cancer Research, Oslo, Norway.
Stephen K Van Den EedenDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Lawrence S EngelDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. Electronic address: Larry.Engel@unc.edu.
National Cancer Institute · USUniversity of North Carolina at Chapel Hill · USCancer Registry of Norway · NOCleveland Clinic · USKaiser Permanente · USLund University · SERutgers, The State University of New Jersey · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Biostatstics for Research in Environmental HealthT32ES007018 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Rebecca Fry · 1985 to 2026
$31.3M
Cancer Control Education ProgramT32CA057726 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa B Gilkey, Melissa A. Troester · 2017 to 2026
$3.7M
Serum Organochlorine Levels and Primary Liver Cancer: A Nested Case-Control StudyR01ES014662 · NIEHS · SLOAN-KETTERING INST CAN RESEARCH · PI SATAGOPAN, JAYA M · 2007 to 2009
$2.3M
Study of exposures and biomarkers in cancer epidemiologyR01CA197402 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SATAGOPAN, JAYA M · 2016 to 2019
$1.6M
NCI NIH HHS R01 CA197402NCI NIH HHS T32 CA057726NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES014662NIEHS NIH HHS T32 ES007018
6 · The paper itself

Abstract

backgroundPolychlorinated biphenyls (PCBs) were used in electrical equipment and a range of construction materials. Although banned in the United States and most of Europe in the 1970s, they are highly persistent in the environment and bioaccumulate. Whether PCBs are associated with liver cancer risk at general population levels is unknown.

methodsThis study consisted of 136 incident liver cancer cases and 408 matched controls from the Kaiser Permanente Northern California Multiphasic Health Checkup (MHC) cohort and 84 cases and 252 matched controls from the Norwegian Janus cohort. Sera collected in the 1960s-1980s were measured for 37 PCB congeners and markers of hepatitis B (HBV) and C (HCV) infection. Odds ratios (OR) and 95% confidence intervals (CI) for tertiles of each lipid-adjusted PCB were estimated from conditional logistic regression. We also examined the molar sum of congeners in groups: total PCBs; low, medium, and high chlorination; and Wolff functional groups.

resultsConcentrations of individual congeners from the 1960s/1970s sera ranged from 1.3-123.0 and 1.4-116.0 ng/g lipid among MHC cases and controls, respectively, and from 1.9-258.0 and 1.9-271.0 ng/g lipid among Janus cases and controls, respectively. Among MHC participants with sera from the 1960s, collected an average of 27 years before diagnosis among cases, the top tertile of PCBs 151, 170, 172, 177, 178, 180, and 195 was significantly associated with elevated odds of liver cancer (OR range = 2.01-2.38); most of these congeners demonstrated exposure-response trends. For example, OR DISCUSSION: We observed associations between a number of PCB congeners and increased odds of liver cancer among MHC, but not Janus, participants with sera from the 1960s/1970s.

Indexed as

Environmental PollutantsLiver NeoplasmsPolychlorinated BiphenylsCase-Control StudiesEuropeHumansNorwayProspective StudiesEnvironmental PollutantsPolychlorinated BiphenylsHepatitis B and CLiver cancerPCBsPersistent exposurePolychlorinated biphenyls

Identifiers

PMID32474310
PMCPMC7317661
OpenAlexW3027271784

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.