Evidence map›Paper›PMID 32474092›Full record

ArticleWorld neurosurgery2020

Coronavirus 2019 (COVID-19)-Associated Encephalopathies and Cerebrovascular Disease: The New Orleans Experience.

Tyler Scullen, Joseph Keen, Mansour Mathkour, Aaron S Dumont, Lora Kahn

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World neurosurgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 18 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 18 syntheses or guidelines pooled it, 109 citations in OpenAlex.

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  5. COVID-19 associated brain/spinal cord lesions and leptomeningeal enhancement: A meta-analysis of the relationship to CSF SARS-CoV-2.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021
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  8. Stroke as a Neurological Complication of COVID-19: A Systematic Review and Meta-Analysis of Incidence, Outcomes and Predictors.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021
    Pooled it
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  10. COVID-19, de novo seizures, and epilepsy: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
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  12. Intracranial hemorrhage in coronavirus disease 2019 (COVID-19) patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
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  13. Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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  17. Neurological manifestations of coronavirus infections - a systematic review.Annals of clinical and translational neurology · 2020
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  18. Neurological Complications of COVID-19 and Possible Neuroinvasion Pathways: A Systematic Review.International journal of environmental research and public health · 2020
    Pooled it
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tyler ScullenDepartment of Neurological Surgery, Ochsner Medical Center, Jefferson, USA; Department of Neurological Surgery, Tulane Medical Center, New Orleans, Louisiana, USA.
Joseph KeenDepartment of Neurological Surgery, Ochsner Medical Center, Jefferson, USA.
Mansour MathkourDepartment of Neurological Surgery, Ochsner Medical Center, Jefferson, USA; Department of Neurological Surgery, Tulane Medical Center, New Orleans, Louisiana, USA.
Aaron S DumontDepartment of Neurological Surgery, Ochsner Medical Center, Jefferson, USA; Department of Neurological Surgery, Tulane Medical Center, New Orleans, Louisiana, USA.
Lora KahnDepartment of Neurological Surgery, Ochsner Medical Center, Jefferson, USA. Electronic address: tylerscullen@gmail.com.
Ochsner Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe coronavirus 2019 (COVID-19) pandemic has had a dramatic impact on health care systems and a variable disease course. Emerging evidence demonstrates that severe acute respiratory syndrome coronavirus 2 is associated with central nervous system disease. We describe central nervous system manifestations in critical patients with COVID-19 at our tertiary center.

methodsWe conducted a single-center retrospective analysis of all actively critical patients with COVID-19 admitted to our tertiary care academic center in New Orleans, Louisiana, on April 22, 2020, with new onset of neurologic disease. Patients were grouped into 1 of 3 categories according to imaging and clinical features; encephalopathy, acute necrotizing encephalopathy, and vasculopathy.

resultsA total of 27 of 76 (35.5%) critical patients with COVID-19 met inclusion criteria. Twenty patients (74%) were designated with COVID-19-associated encephalopathy, 2 (7%) with COVID-19-associated acute necrotizing encephalopathy, and 5 (19%) with COVID-19-associated vasculopathy. Sixty-three percent of neurologic findings were demonstrated on computed tomography, 30% on magnetic resonance imaging, and 44% on electroencephalography. Findings most often included ischemic strokes, diffuse hypoattenuation, subcortical parenchymal hemorrhages, and focal hypodensities within deep structures. Magnetic resonance imaging findings included diffuse involvement of deep white matter, the corpus callosum, and the basal ganglia. For patients with large-territory ischemic stroke, all but one displayed irregular proximal focal stenosis of the supraclinoid internal carotid artery.

conclusionsAnalysis of active critical COVID-19 admissions at our revealed a high percentage of patients with new neurologic disease. Although variable, presentations followed 1 of 3 broad categories. A better understanding of the neurologic sequalae and radiographic findings will help clinicians mitigate the impact of this disease.

Indexed as

AdultAgedAged, 80 and overBrain DiseasesBrain IschemiaCerebrovascular DisordersComorbidityCoronavirus InfectionsCOVID-19Critical CareCross-Sectional StudiesElectroencephalographyFemaleHumansLeigh DiseaseLouisianaCerebrovascular diseaseInfectious diseaseNeurologic surgerySAR-CoV-2

Identifiers

PMID32474092
PMCPMC7255727
OpenAlexW3030760530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.