ArticleBrain, behavior, and immunity2020
Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study.
Article in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Genetics and epigenetics of self-injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022Pooled it
- Inflammatory indices are associated with non-suicidal self-injury in adolescents with major depressive disorder.BMC psychiatry · 2025Article
- Associations between peripheral plasma cytokine levels and patterns of non-suicidal self-injury methods among Chinese outpatient adolescents: a latent class analysis.BMC psychiatry · 2025Article
- SNP-associated differential methylation inEpigenomics · 2025Article
- The role of cytokines in predicting the therapeutic effect of non-suicidal self-injury in adolescents: a longitudinal study.BMC psychiatry · 2025Article
- Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament.Frontiers in molecular neuroscience · 2025Article
- Prognostic value of preoperative systemic immune-inflammation index/albumin for patients with hepatocellular carcinoma undergoing curative resection.World journal of gastroenterology · 2024Article
- Mendelian randomization analysis using multiple biomarkers of an underlying common exposure.Biostatistics (Oxford, England) · 2024Article
- Causal Effects of COVID-19 on the Risk of Thrombosis: A Two-Sample Mendel Randomization Study.Thrombosis and haemostasis · 2024Article
- A cross-sectional study of non-suicidal self-injury in adolescent depression: association with demographic characteristics and physiological indicators.Frontiers in psychiatry · 2024Article
- Using the Strategy of Genome-Wide Association Studies to Identify Genetic Markers of Suicidal Behavior: A Narrative Review.Consortium psychiatricum · 2024Review
- Association of monocyte-lymphocyte ratio and myocardial infarction in the U.S. population with diabetes.Frontiers in cardiovascular medicine · 2024Article
- COVID-19 host genetics and ABO blood group susceptibility.Cambridge prisms. Precision medicine · 2023Review
- The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study.Frontiers in immunology · 2023Article
- Elevated levels of monocyte-lymphocyte ratio and platelet-lymphocyte ratio in adolescents with non-suicidal self-injury.BMC psychiatry · 2022Article
- Network science approach elucidates integrative genomic-metabolomic signature of antidepressant response and lifetime history of attempted suicide in adults with major depressive disorder.Frontiers in pharmacology · 2022Article
- Raised C-reactive protein in medication overdose: A report of two cases.SAGE open medical case reports · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe causal role of inflammatory markers on self-harm and suicidal risk has been studied using observational data, with conflicting results. Confounding and reverse causation can lead to bias, so we appraised question from a genetic perspective to protect against these biases. We measured associations between genetic liability for high levels of inflammatory markers Interleukin-6 (IL-6) and C-reactive protein (CRP) on self-harm, and conducted a secondary analysis restricted to self-harm with suicidal intent.
methodsWe conducted two sample and multivariable Mendelian randomisation (MR) to assess the effects of IL-6 and CRP on self-harm utilising existing data and conducting new genome wide association studies to instrument IL-6 and CRP, and for the outcome of self-harm.
resultsNo single nucleotide polymorphisms (SNPs) reached genome-wide significance for self-harm, however 193 SNPs met suggestive significance levels (p < 5 × 10
conclusionsOur findings are conflicting and indicate that IL-6 and CRP are not robust etiological markers of increased self-harm or suicide risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.