ArticleJournal of molecular biology2020
Both N-Terminal and C-Terminal Histidine Residues of the Prion Protein Are Essential for Copper Coordination and Neuroprotective Self-Regulation.
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Article in Journal of molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Cellular prion protein and its derived peptides: multifaceted roles in neurodegenerative diseases and potential as biomarkers.Cell & bioscience · 2026Review
- Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases.MedComm · 2026Review
- Structural insights into copper and zinc binding to tau protein and the impact of metal binding on amyloid aggregation.Chemical science · 2026Article
- Substitution of histidine 95 by tyrosine in the prion protein causes spontaneous neurodegeneration in transgenic mice.PLoS pathogens · 2025Article
- Segmental Isotope Labeling of the Prion Protein: Identification of a Key Residue for Copper-Mediated Interdomain Structure.ACS chemical biology · 2025Article
- Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice.The Journal of clinical investigation · 2025Article
- A Copper-Binding Peptide with Therapeutic Potential against Alzheimer's Disease: From the Blood-Brain Barrier to Metal Competition.ACS chemical neuroscience · 2025Article
- Deuterium trafficking, mitochondrial dysfunction, copper homeostasis, and neurodegenerative disease.Frontiers in molecular biosciences · 2025Review
- The interaction of Cu(II) and Zn(II) with peptide fragment of HSPB1 and its analogs.Frontiers in molecular biosciences · 2025Article
- Prion Protein Endoproteolysis: Cleavage Sites, Mechanisms and Connections to Prion Disease.Journal of neurochemistry · 2025Review
- Review
- Copper coordination modulates prion conversion and infectivity in mammalian prion proteins.Prion · 2023Review
- Article
- Copper drives prion protein phase separation and modulates aggregation.Science advances · 2023Article
- Inducing prion protein shedding as a neuroprotective and regenerative approach in pathological conditions of the brain: from theory to facts.Neural regeneration research · 2023Review
- Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity.Brain pathology (Zurich, Switzerland) · 2023Article
- Heat shock proteins and metal ions - Reaction or interaction?Computational and structural biotechnology journal · 2023Review
- Structural and dynamical determinants of a β-sheet-enriched intermediate involved in amyloid fibrillar assembly of human prion protein.Chemical science · 2022Article
- Melatonin: Regulation of Prion Protein Phase Separation in Cancer Multidrug Resistance.Molecules (Basel, Switzerland) · 2022Review
- EPR of copper centers in the prion protein.Methods in enzymology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Kevin M SchillingDepartment of Chemistry and Biochemistry, University of California, 1156 High Street, Santa Cruz, CA 95064, USA.
Lizhi TaoDepartment of Chemistry, University of California, 1 Shields Ave., Davis, CA 95616, USA.
Bei WuDepartment of Biochemistry, Boston University School of Medicine, 72 E. Concord St Silvio Conte., Boston, MA 02118, USA.
Joseph T M KiblenDepartment of Chemistry and Biochemistry, University of California, 1156 High Street, Santa Cruz, CA 95064, USA.
Natalia C Ubilla-RodriguezDepartment of Chemistry and Biochemistry, University of California, 1156 High Street, Santa Cruz, CA 95064, USA.
M Jake PushieDepartment of Surgery, College of Medicine, University of Saskatchewan, 107 Wiggins Rd B419, Saskatoon, SK S7N 5E5, Canada.
R David BrittDepartment of Chemistry, University of California, 1 Shields Ave., Davis, CA 95616, USA.
Graham P RosemanDepartment of Chemistry and Biochemistry, University of California, 1156 High Street, Santa Cruz, CA 95064, USA.
David A HarrisDepartment of Biochemistry, Boston University School of Medicine, 72 E. Concord St Silvio Conte., Boston, MA 02118, USA. Electronic address: daharris@bu.edu.
Glenn L MillhauserDepartment of Chemistry and Biochemistry, University of California, 1156 High Street, Santa Cruz, CA 95064, USA. Electronic address: glennm@ucsc.edu.
University of California, Santa Cruz · USBoston University · USUniversity of California, Davis · USUniversity of Saskatchewan · CA
Funding
UNIVERSITY OF CALIFORNIA, SANTA CRUZ IMSD PROGRAMR25GM058903 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI JURICA, MELISSA S · 1999 to 2019
$12.2MMechanisms of Prion Protein ToxicityR01NS065244 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HARRIS, DAVID A · 2010 to 2025
$8.9MMolecular Aspects of Copper Binding to the Prion ProteinR01GM065790 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MILLHAUSER, GLENN L · 2002 to 2018
$4.5MSupplement:Spectroscopy Investigations of Metalloenzyme MechanismsR35GM126961 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI R. David Britt · 2018 to 2026
$3.7MSupplement Request for Emergency Replacement of EPR Amplifier and Acquisition of a Low Volume Resonator for Membrane ProteinsR35GM131781 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI GLENN L MILLHAUSER · 2019 to 2026
$3.6M800 MHz NMR Spectrometer and Helium CryoprobeS10OD018455 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MILLHAUSER, GLENN L · 2015 to 2015
$2.0MUpgrade of a Pulsed Electron Paramagnetic Resonance SpectrometerS10OD024980 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MILLHAUSER, GLENN L · 2018 to 2018
$1.5MNIGMS NIH HHS R01 GM065790NIGMS NIH HHS R25 GM058903NIGMS NIH HHS R35 GM126961NIGMS NIH HHS R35 GM131781NIH HHS S10 OD018455NIH HHS S10 OD024980NINDS NIH HHS R01 NS065244
Abstract
The cellular prion protein (PrP
Indexed as
MutationAnimalsCopperDNA Repeat ExpansionHistidineMiceModels, MolecularMolecular Dynamics SimulationPrion ProteinsProtein ConformationProtein DomainsProtein FoldingCopperHistidinePrion ProteinsPrnp protein, mouseAβ42EPRNMRPrPPrPC
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.