Evidence map›Paper›PMID 32473857›Full record

GuidelinePractical radiation oncology

Radiation Therapy for Cervical Cancer: Executive Summary of an ASTRO Clinical Practice Guideline.

Junzo Chino, Christina M Annunziata, Sushil Beriwal, Lisa Bradfield, Beth A Erickson, Emma C Fields, KathrynJane Fitch, Matthew M Harkenrider, Christine H Holschneider, Mitchell Kamrava and 7 more

Open access · bronzeAbstract readPractice Guideline
In one paragraph

Guideline in Practical radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 1 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 1 synthesis or guideline pooled it, 286 citations in OpenAlex.

  1. Point-A vs. volume-based brachytherapy for the treatment of cervix cancer: A meta-analysis.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2022
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. HAR-Net: Automatic delineation of clinical target volumes for cervical cancer guided by hierarchical anatomical refinement.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Brachytherapy use in cervical cancer: a narrative review.Gynecology and pelvic medicine · 2026
    Review
  18. Automatic pelvic bone segmentation for radiotherapy using diagnostic imaging workstation.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026
    Article
  19. Article
  20. Article

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 15 institutions in 2 countries.

Junzo ChinoDepartment of Radiation Oncology and Guideline Vice-Chair, Duke University Cancer Center, Durham, North Carolina. Electronic address: junzo.chino@duke.edu.
Christina M AnnunziataWomen's Malignancies Branch, National Cancer Institute, Bethesda, Maryland.
Sushil BeriwalDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
Lisa BradfieldAmerican Society for Radiation Oncology, Arlington, Virginia.
Beth A EricksonDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Emma C FieldsDepartment of Radiation Oncology, Virginia Commonwealth University, Richmond, Virgina.
KathrynJane FitchPatient Representative, Charlotte, North Carolina.
Matthew M HarkenriderDepartment of Radiation Oncology, Loyola University Chicago, Chicago, Illinois; Department of Radiation Oncology, Edward Hines Jr. VA Hospital, Hines, Illinois.
Christine H HolschneiderDepartment of Obstetrics and Gynecology, Olive View/UCLA Medical Center, Sylmar, California.
Mitchell KamravaDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, California.
Eric LeungDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Odette Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
Lilie L LinDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, Texas.
Jyoti S MayadevDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, California.
Marc MorcosDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, Maryland.
Chika NwachukwuDepartment of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas.
Daniel PetereitDepartment of Radiation Oncology, Rapid City Regional Health, Rapid City, South Dakota.
Akila N ViswanathanDepartment of Radiation Oncology and Molecular Radiation Sciences and Guideline Chair, Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University · USAmerican Society for Radiation Oncology · USCedars-Sinai Medical Center · USDuke University · USLoyola University Chicago · USMedical College of Wisconsin · USNational Cancer Institute · USOlive View-UCLA Medical Center · USRegional Health · USSouthwestern Medical Center · USSunnybrook Health Science Centre · CAThe University of Texas MD Anderson Cancer Center · USUniversity of California San Diego · USUPMC Hillman Cancer Center · USVirginia Commonwealth University · US

Funding

Clinical trials in womens cancersZIABC011584 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ANNUNZIATA, CHRISTINA · 2014 to 2023
$3.1M
Intramural NIH HHS ZIA BC011584
6 · The paper itself

Abstract

purposeThis guideline reviews the evidence and provides recommendations for the indications and appropriate techniques of radiation therapy (RT) in the treatment of nonmetastatic cervical cancer.

methodsThe American Society for Radiation Oncology convened a task force to address 5 key questions focused on the use of RT in definitive and postoperative management of cervical cancer. These questions included the indications for postoperative and definitive RT, the use of chemotherapy in sequence or concurrent with RT, the use of intensity modulated radiation therapy (IMRT), and the indications and techniques of brachytherapy. Recommendations were based on a systematic literature review and created using a predefined consensus-building methodology and system for grading evidence quality and recommendation strength.

resultsThe guideline recommends postoperative RT for those with intermediate risk factors, and chemoradiation for those with high-risk factors. In the definitive setting, chemoradiation is recommended for stages IB3-IVA, and RT or chemoradiation is conditionally recommended for stages IA1-IB2 if medically inoperable. IMRT is recommended for postoperative RT and conditionally recommended for definitive RT, for the purposes of reducing acute and late toxicity. Brachytherapy is strongly recommended for all women receiving definitive RT, and several recommendations are made for target dose and fractionation, the use of intraoperative imaging, volume-based planning, and recommendations for doses limits for organs at risk.

conclusionsThere is strong evidence supporting the use of RT with or without chemotherapy in both definitive and postoperative settings. Brachytherapy is an essential part of definitive management and volumetric planning is recommended. IMRT may be used for the reduction of acute and late toxicity. The use of radiation remains an essential component for women with cervical cancer to achieve cure.

Indexed as

FemaleHumansRadiation OncologyUterine Cervical Neoplasms

Identifiers

PMID32473857
PMCPMC8802172
OpenAlexW2970226356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.