Evidence map›Paper›PMID 32473844›Full record

ArticleBehavioural brain research2020

A limited range of vagus nerve stimulation intensities produce motor cortex reorganization when delivered during training.

Robert A Morrison, Tanya T Danaphongse, David T Pruitt, Katherine S Adcock, Jobin K Mathew, Stephanie T Abe, Dina M Abdulla, Robert L Rennaker, Michael P Kilgard, Seth A Hays

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

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  16. Narrative Review of Noninvasive Brain Stimulation in Stroke Rehabilitation.Medical science monitor : international medical journal of experimental and clinical research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Robert A MorrisonThe University of Texas at Dallas, School of Behavioral Brain Sciences, Richardson, TX, United States; The University of Texas at Dallas, Texas Biomedical Device Center, Richardson, TX, United States. Electronic address: robert.morrison@utdallas.edu.
Tanya T DanaphongseThe University of Texas at Dallas, Texas Biomedical Device Center, Richardson, TX, United States.
David T PruittThe University of Texas at Dallas, Texas Biomedical Device Center, Richardson, TX, United States.
Katherine S AdcockThe University of Texas at Dallas, School of Behavioral Brain Sciences, Richardson, TX, United States; The University of Texas at Dallas, Texas Biomedical Device Center, Richardson, TX, United States.
Jobin K MathewThe University of Texas at Dallas, Texas Biomedical Device Center, Richardson, TX, United States.
Stephanie T AbeThe University of Texas at Dallas, Texas Biomedical Device Center, Richardson, TX, United States.
Dina M AbdullaThe University of Texas at Dallas, School of Behavioral Brain Sciences, Richardson, TX, United States; The University of Texas at Dallas, Texas Biomedical Device Center, Richardson, TX, United States.
Robert L RennakerThe University of Texas at Dallas, School of Behavioral Brain Sciences, Richardson, TX, United States; The University of Texas at Dallas, Texas Biomedical Device Center, Richardson, TX, United States.
Michael P KilgardThe University of Texas at Dallas, School of Behavioral Brain Sciences, Richardson, TX, United States; The University of Texas at Dallas, Texas Biomedical Device Center, Richardson, TX, United States.
Seth A HaysThe University of Texas at Dallas, Texas Biomedical Device Center, Richardson, TX, United States; The University of Texas at Dallas, Erik Jonsson School of Engineering and Computer Science, Richardson, TX, United States.
Texas Biomedical Research Institute · USThe University of Texas at Dallas · US

Funding

Vagus Nerve Stimulation Paired with Rehabilitative Training to Enhance PlasticityR01NS085167 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI KILGARD, MICHAEL P, RENNAKER, ROBERT L · 2014 to 2018
$1.9M
Evaluation of the Neuromodulatory Mechanisms of Vagus Nerve Stimulation to Improve Motor Rehabilitation after StrokeR01NS094384 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI HAYS, SETH ALANSON · 2016 to 2020
$1.7M
NINDS NIH HHS R01 NS085167NINDS NIH HHS R01 NS094384
6 · The paper itself

Abstract

Pairing vagus nerve stimulation (VNS) with rehabilitation has emerged as a potential strategy to improve recovery after neurological injury, an effect ascribed to VNS-dependent enhancement of synaptic plasticity. Previous studies demonstrate that pairing VNS with forelimb training increases forelimb movement representations in motor cortex. However, it is not known whether VNS-dependent enhancement of plasticity is restricted to forelimb training or whether VNS paired with other movements could induce plasticity of other motor representations. We tested the hypothesis that VNS paired with orofacial movements associated with chewing during an unskilled task would drive a specific increase in jaw representation in motor cortex compared to equivalent behavioral experience without VNS. Rats performed a behavioral task in which VNS at a specified intensity between 0 and 1.2 mA was paired with chewing 200 times per day for five days. Intracortical microstimulation (ICMS) was then used to document movement representations in motor cortex. VNS paired with chewing at 0.8 mA significantly increased motor cortex jaw representation compared to equivalent behavioral training without stimulation (Bonferroni-corrected unpaired t-test, p < 0.01). Higher and lower intensities failed to alter cortical plasticity. No changes in other movement representations or total motor cortex area were observed between groups. These results demonstrate that 0.8 mA VNS paired with training drives robust plasticity specific to the paired movement, is not restricted to forelimb representations, and occurs with training on an unskilled task. This suggests that moderate intensity VNS may be a useful adjuvant to enhance plasticity and support benefits of rehabilitative therapies targeting functions beyond upper limb movement.

Indexed as

AnimalsChromosome PairingConditioning, PsychologicalFemaleMasticationMotor CortexMovementNeuronal PlasticityNeuronsRatsRats, Sprague-DawleyVagus NerveVagus Nerve StimulationCortical reorganizationIntracortical microstimulationMotor cortexOrofacial activityVagus nerve stimulation

Identifiers

PMID32473844
PMCPMC7413489
OpenAlexW3030621843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.