Evidence map›Paper›PMID 32473745›Full record

ReviewTrends in genetics : TIG2020

Taming the Turmoil Within: New Insights on the Containment of Transposable Elements.

Erin S Kelleher, Daniel A Barbash, Justin P Blumenstiel

Open access · greenAbstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Transposon Ecology and the Octopus Genome.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  8. Article
  9. Polymorphic 3D genome architecture mediated by transposable elements.bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Erin S KelleherUniversity of Houston, Houston, TX 77204, USA. Electronic address: eskelleher@uh.edu.
Daniel A BarbashCornell University, Ithaca, NY 14853, USA.
Justin P BlumenstielUniversity of Kansas, Lawrence, KS 66045, USA.
Cornell University · USUniversity of Houston · USUniversity of Kansas · US

Funding

Molecular Genetics of Drosophila Hybrid LethalityR01GM074737 · NIGMS · CORNELL UNIVERSITY ITHACA · PI BARBASH, DANIEL A · 2005 to 2022
$4.7M
Heterochromatin and satellite repeat sequence variation in natural populationsR01GM119125 · NIGMS · CORNELL UNIVERSITY · PI BARBASH, DANIEL A, CLARK, ANDREW G · 2017 to 2020
$1.3M
NIGMS NIH HHS R01 GM074737NIGMS NIH HHS R01 GM119125
6 · The paper itself

Abstract

Transposable elements (TEs) are mobile genetic parasites that can exponentially increase their genomic abundance through self-propagation. Classic theoretical papers highlighted the importance of two potentially escalating forces that oppose TE spread: regulated transposition and purifying selection. Here, we review new insights into mechanisms of TE regulation and purifying selection, which reveal the remarkable foresight of these theoretical models. We further highlight emergent connections between transcriptional control enacted by small RNAs and the contribution of TE insertions to structural mutation and host-gene regulation. Finally, we call for increased comparative analysis of TE dynamics and fitness effects, as well as host control mechanisms, to reveal how interconnected forces shape the differential prevalence and distribution of TEs across the tree of life.

Indexed as

Evolution, MolecularModels, GeneticSelection, GeneticAnimalsDNA Transposable ElementsHumansRNA InterferenceDNA Transposable Elementsgenome evolutionheterochromatic spreadingpiRNA pathwaysynergistic epistasistransposable elements

Identifiers

PMID32473745
PMCPMC7347376
OpenAlexW3030373994

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.