ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 46 citations in OpenAlex.
- Dose-Dependent Effects of Catecholaminergic Modulation on Interference Control: Role of Baseline GABA and Glx in Cortico-Subcortical Networks.Human brain mapping · 2025Trial
- Methylphenidate differentially alters corticostriatal connectivity after traumatic brain injury.Brain : a journal of neurology · 2025Trial
- Catecholaminergic Modulation of Large-Scale Network Dynamics Is Tied to the Reconfiguration of Corticostriatal Connectivity.Human brain mapping · 2024Trial
- Brain connectivity changes to fast versus slow dopamine increases.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Do Stimulants Promote Arrhythmic Risk: Insights From a Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Model.Journal of arrhythmia · 2026Article
- Spatial Collinearity Constrains Multivariate Molecular-Enriched Network Estimation.Human brain mapping · 2026Article
- Kynurenine pathway dysregulation in attention-deficit hyperactivity disorder: Impact on N-methyl-D-aspartate receptors and phasic dopamine maturation.World journal of clinical pediatrics · 2026Review
- Investigating the Contribution of Molecular-Enriched Functional Connectivity to Brain-Age Analysis.Human brain mapping · 2026Article
- Feasibility, Safety, and Exploratory Outcomes of Methylphenidate for Posttraumatic Stress Disorder Among Patients With Ischemic Stroke.International journal of psychiatry in medicine · 2026Article
- Spatial collinearity constrains multivariate molecular-enriched network estimation.bioRxiv : the preprint server for biology · 2026Article
- Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Linking human brain functional connectivity to underlying neurotransmission.bioRxiv : the preprint server for biology · 2026Article
- Functional Magnetic Resonance Imaging Signal Typically Viewed as "Noise" Has Clinical Relevance in Psychiatry.Biological psychiatry global open science · 2026Article
- Associations with Methylphenidate Treatment in Emotion Regulation and Skin-Picking Severity in Adolescents with Attention-Deficit/Hyperactivity Disorder: A Clinical Follow-Up Study.Journal of clinical medicine · 2026Article
- Exercise-Induced modulation of molecular-enriched functional connectivity in Parkinson's disease.Journal of Parkinson's disease · 2026Article
- Pharmacological MRI: Utility in Understanding Drug Mechanisms in Psychiatric Disorders.Journal of magnetic resonance imaging : JMRI · 2026Review
- Article
- Reviewing vascular influences on neuronal migration, cortical development, and neurodevelopmental disorders: focus on autism, ADHD and schizophrenia.Molecular psychiatry · 2025Review
- Investigating the Contribution of Molecular-Enriched Functional Connectivity to Brain-Age Analysis.bioRxiv : the preprint server for biology · 2025Article
- Systemic physiological "noise" in fMRI has clinical relevance.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional magnetic resonance imaging (fMRI) can be combined with drugs to investigate the system-level functional responses in the brain to such challenges. However, most psychoactive agents act on multiple neurotransmitters, limiting the ability of fMRI to identify functional effects related to actions on discrete pharmacological targets. We recently introduced a multimodal approach, REACT (Receptor-Enriched Analysis of functional Connectivity by Targets), which offers the opportunity to disentangle effects of drugs on different neurotransmitters and clarify the biological mechanisms driving clinical efficacy and side effects of a compound. Here, we focus on methylphenidate (MPH), which binds to the dopamine transporter (DAT) and the norepinephrine transporter (NET), to unravel its effects on dopaminergic and noradrenergic functional circuits in the healthy brain at rest. We then explored the relationship between these target-enriched resting state functional connectivity (FC) maps and inter-individual variability in behavioural responses to a reinforcement-learning task encompassing a novelty manipulation to disentangle the molecular systems underlying specific cognitive/behavioural effects. Our main analysis showed a significant MPH-induced FC increase in sensorimotor areas in the functional circuit associated with DAT. In our exploratory analysis, we found that MPH-induced regional variations in the DAT and NET-enriched FC maps were significantly correlated with some of the inter-individual differences on key behavioural responses associated with the reinforcement-learning task. Our findings show that main MPH-related FC changes at rest can be understood through the distribution of DAT in the brain. Furthermore, they suggest that when compounds have mixed pharmacological profiles, REACT may be able to capture regional functional effects that are underpinned by the same cognitive mechanism but are related to engagement of distinct molecular targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.