ReviewMechanisms of development2020
Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate.
Review in Mechanisms of development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
80 citing papers in PubMed, 158 citations in OpenAlex.
- Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026Review
- Regulation of mRNA poly(A) tail length governs mammalian body plan formation in gastruloids.Nature communications · 2026Article
- AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs.Developmental cell · 2026Article
- Putting mammalian early embryonic cells into dormancy.Nature protocols · 2026Review
- Mosaic gastruloids reveal a temporal restriction for developmental cell competition.Nature cell biology · 2026Article
- YAP1 and QSER1 are key modulators of embryonic signaling pathways in the mammalian epiblast.EMBO reports · 2026Article
- From genes to germ layers: virtual twins of gastruloids.NPJ systems biology and applications · 2026Review
- Mechanisms Underlying the Initiation and Termination of Collective Cell Migration: Perspectives for Understanding Development and Cancer Metastasis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- High resolution spatial transcriptomic and proteomic profiling of early primate gastrulationbioRxiv : the preprint server for biology · 2026Article
- Integrated multi-omic atlas reveals the hierarchy of spatiotemporal regulatory networks of mouse gastrulation.Nature communications · 2026Article
- The Role of the Hedgehog Pathway in Alcohol-Induced Birth Defects.Advances in experimental medicine and biology · 2026Review
- Human Organoids Reveal PTEN-Driven Mesendoderm Specification via Retinoic Acid Signaling Suppression.Research (Washington, D.C.) · 2026Article
- Why and How Are Infants with Hutchinson-Gilford Progeria Syndrome Born Without Severe Manifestations?Medical sciences (Basel, Switzerland) · 2025Review
- Enhancer remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm.Developmental cell · 2025Article
- Dissecting Oct4 enhancer function in pluripotent stem cells and mouse embryogenesis.Stem cell reports · 2025Article
- Loss of CMTR1 leads to gastrulation failure and early embryonic lethality.Developmental biology · 2025Article
- Extracellular presentation of syntaxin4 as a potential trigger for region-specific gastrulation.Cell structure and function · 2025Article
- Posterior enhancer (p-Enh) maintains early neuromesodermal progenitors bi-potency during gastrulation.Cell regeneration (London, England) · 2025Article
- Heat Shock Differentially Compromises Embryonic Development and Gene Expression in a Mouse Embryoid Body Model System.Animals : an open access journal from MDPI · 2025Article
- Characterization of the mammalian prodefinitive angio-hematopoietic lineage.Science immunology · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During mouse embryonic development a mass of pluripotent epiblast tissue is transformed during gastrulation to generate the three definitive germ layers: endoderm, mesoderm, and ectoderm. During gastrulation, a spatiotemporally controlled sequence of events results in the generation of organ progenitors and positions them in a stereotypical fashion throughout the embryo. Key to the correct specification and differentiation of these cell fates is the establishment of an axial coordinate system along with the integration of multiple signals by individual epiblast cells to produce distinct outcomes. These signaling domains evolve as the anterior-posterior axis is established and the embryo grows in size. Gastrulation is initiated at the posteriorly positioned primitive streak, from which nascent mesoderm and endoderm progenitors ingress and begin to diversify. Advances in technology have facilitated the elaboration of landmark findings that originally described the epiblast fate map and signaling pathways required to execute those fates. Here we will discuss the current state of the field and reflect on how our understanding has shifted in recent years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.