ArticleJournal of occupational and environmental medicine2020
[11C]dihydrotetrabenazine Positron Emission Tomography in Manganese-Exposed Workers.
Susan R Criswell, Susan Searles Nielsen, Mark N Warden, Joel S Perlmutter, Stephen M Moerlein, Lianne Sheppard, Jason Lenox-Krug, Harvey Checkoway, Brad A Racette
Article in Journal of occupational and environmental medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors at 2 institutions in 2 countries.
Susan R CriswellDepartment of Neurology (Dr Criswell, Dr Nielsen, Mr Warden, Dr Perlmutter, Mr Lenox-Krug, Dr Racette); Department of Radiology (Dr Perlmutter, Dr Moerlein); Department of Neuroscience (Dr Perlmutter); Program in Physical Therapy (Dr Perlmutter); Program in Occupational Therapy (Dr Perlmutter); Department of Biochemistry and Molecular Biophysics (Dr Moerlein), Washington University School of Medicine, St. Louis, Missouri ; Department of Environmental and Occupational Health Sciences (Dr Sheppard); Department of Biostatistics (Dr Sheppard), School of Public Health, University of Washington, Seattle, Washington; Department of Family Medicine and Public Health (Dr Checkoway); Department of Neurosciences (Dr Checkoway), School of Medicine, University of California, San Diego, La Jolla, California; Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Parktown, South Africa (Dr Racette).
Susan Searles Nielsen
Mark N Warden
Joel S Perlmutter
Stephen M Moerlein
Lianne Sheppard
Jason Lenox-Krug
Harvey Checkoway
Brad A Racette
Sheppard and Enoch Pratt Hospital · USDraper Laboratory · US
Funding
WILDLIFE BIOMARKER APPLICATIONS TO REMEDIATION DECISION MAKINGP42ES004696 · NIEHS · UNIVERSITY OF WASHINGTON · PI NEUMANN, REBECCA B · 1987 to 2021
$51.2M
The ESPINA Study Follow-up Examination in 2016: Environmental Pollutants and Child/Adolescent DevelopmentR01ES025792 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Raeanne Cristine Moore, Jose Ricardo Suarez · 2016 to 2026
$5.6M
Imaging Biomarkers of Neurotoxicity in WeldersR01ES021488 · NIEHS · WASHINGTON UNIVERSITY · PI Brad A Racette · 2013 to 2026
$5.3M
Air Pollution, the Aging Brain and Alzheimer's DiseaseR01ES026187 · NIEHS · UNIVERSITY OF WASHINGTON · PI LI, GAIL, SHEPPARD, ELIZABETH A LIANNE · 2016 to 2020
$3.8M
Motor and Cognitive Health Outcomes in a Mn-Exposed African CommunityR01ES025991 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2015 to 2019
$3.7M
Manganese-Induced Neurotoxic Effects Research in South Africa (MINERS)R01ES026891 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2017 to 2021
$3.3M
NOVEL PET MARKERS OF COGNITIVE IMPAIRMENT IN MANGANESENEUROTOXICITYR01ES029524 · NIEHS · WASHINGTON UNIVERSITY · PI CRISWELL, SUSAN · 2019 to 2023
$3.3M
Epidemiology of Parkinsonism in WeldersR01ES013743 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2007 to 2011
$2.6M
Epidemiology and Biomarkers of Parkinsonism in WeldersK24ES017765 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2009 to 2018
$1.5M
RESTING STATE FUNCTIONAL CONNECTIVITY MRI IN MANGANESE EXPOSED WELDERSK23ES021444 · NIEHS · WASHINGTON UNIVERSITY · PI CRISWELL, SUSAN · 2012 to 2016
$809k
Pesticides and Mental Health among Adolescents in Ecuadorian Agricultural CommunitiesR21ES026084 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUAREZ, JOSE RICARDO · 2015 to 2016
objectiveTo understand the neurotoxic effects of manganese (Mn) exposure on monoaminergic function, utilizing [C]dihydrotetrabenazine (DTBZ) positron emission tomography (PET) to measure vesicular monoamine transporter 2 (VMAT2).
methodsBasal ganglia and thalamic DTBZ binding potentials (BPND) were calculated on 56 PETs from 41 Mn-exposed workers. Associations between cumulative Mn exposure, regional BPND, and parkinsonism were examined by mixed linear regression.
resultsThalamic DTBZ BPND was inversely associated with exposure in workers with less than 3 mg Mn/m-yrs, but subsequently remained stable. Pallidal DTBZ binding increased in workers with less than 2 mg Mn/m-yrs of exposure, but decreased thereafter. Thalamic DTBZ binding was inversely associated with parkinsonism (P = 0.003).
conclusionMn-dose-dependent associations with thalamic and pallidal DTBZ binding indicate direct effects on monoaminergic VMAT2. Thalamic DTBZ binding was also associated with parkinsonism, suggesting potential as an early biomarker of Mn neurotoxicity.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
[11C]dihydrotetrabenazine Positron Emission Tomography in Manganese-Exposed Workers. · full record | OpenQuestion