Evidence map›Paper›PMID 32472628›Full record

Trial reportAnnals of clinical and translational neurology2020

Remote ischemic conditioning combined with intravenous thrombolysis for acute ischemic stroke.

Yao-De He, Zhen-Ni Guo, Chen Qin, Hang Jin, Peng Zhang, Reziya Abuduxukuer, Yi Yang

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of clinical and translational neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 10 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 10 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Remote ischaemic conditioning for preventing and treating ischaemic stroke.The Cochrane database of systematic reviews · 2025
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  5. Remote ischemic conditioning for stroke: A critical systematic review.International journal of stroke : official journal of the International Stroke Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yao-De HeDepartment of Neurology, Stroke Center, The First Hospital of Jilin University, Chang Chun, Jilin, 130021, China.
Zhen-Ni GuoDepartment of Neurology, Clinical Trial and Research Center for Stroke, The First Hospital of Jilin University, Chang Chun, Jilin, 130021, China.
Chen QinDepartment of Neurology, Stroke Center, The First Hospital of Jilin University, Chang Chun, Jilin, 130021, China.
Hang JinDepartment of Neurology, Stroke Center, The First Hospital of Jilin University, Chang Chun, Jilin, 130021, China.
Peng ZhangDepartment of Neurology, Clinical Trial and Research Center for Stroke, The First Hospital of Jilin University, Chang Chun, Jilin, 130021, China.
Reziya AbuduxukuerDepartment of Neurology, Stroke Center, The First Hospital of Jilin University, Chang Chun, Jilin, 130021, China.
Yi YangDepartment of Neurology, Stroke Center, The First Hospital of Jilin University, Chang Chun, Jilin, 130021, China.ORCID 0000-0002-9729-8522
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study was to investigate the safety and efficacy of remote ischemic conditioning (RIC) combined with intravenous thrombolysis (IVT) in the treatment of acute ischemic stroke (AIS).

methodsPatients with AIS who underwent IVT were enrolled and 1:1 randomized to the RIC group and sham-RIC group in this study. RIC (or sham-RIC) was performed twice within 6-24 h of IVT. The subjects in the two groups were followed up for 90 days. The safety outcome included the ratio of hemorrhagic transformation (HT), adverse events during the follow-up, blood pressure within the first 24 h after IVT, and laboratory tests 24 h after IVT. The efficacy outcome included the modified Rankin Scale (mRS) score, National Institute of Health Stroke Scale (NIHSS) score during the follow-up, and level of high-sensitivity C-reactive protein (hs-CRP) tested 24 h after IVT.

resultsForty-nine patients (24 in the RIC group and 25 in the sham-RIC group) were recruited. No significant difference was observed in the ratio of HT, adverse events, blood pressure, coagulation function or liver function between groups. In addition, there was no significant difference in mRS score and NIHSS score during the follow-up between groups. However, patients in the RIC group exhibited a significant lower level of hs-CRP compared with the control group (P = 0.048).

interpretationRIC combined with IVT is safe in the treatment of AIS. The neuroprotective and anti-inflammatory effects of this therapy warrant further study on a larger scale.

Indexed as

Outcome Assessment, Health CareAdministration, IntravenousAgedCombined Modality TherapyFemaleFibrinolytic AgentsHumansIschemic PostconditioningIschemic StrokeMaleMiddle AgedProspective StudiesReperfusionSingle-Blind MethodThrombolytic TherapyFibrinolytic Agents

Identifiers

PMID32472628
PMCPMC7318096
OpenAlexW3029433159

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.