Evidence map›Paper›PMID 32472526›Full record

ReviewJournal of nephrology2021

Coronary artery disease in dialysis patients: evidence synthesis, controversies and proposed management strategies.

Alexandru Burlacu, Simonetta Genovesi, Carlo Basile, Alberto Ortiz, Sandip Mitra, Dimitrios Kirmizis, Mehmet Kanbay, Andrew Davenport, Frank van der Sande, Adrian Covic and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 6 countries.

Alexandru Burlacu *Department of Interventional Cardiology, Cardiovascular Diseases Institute, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.ORCID 0000-0002-3424-1588
Simonetta Genovesi *Nephrology Unit, San Gerardo Hospital, Monza, Italy, University of Milan-Bicocca, Milan, Italy.ORCID 0000-0002-4699-4149
Carlo BasileDivision of Nephrology, Miulli General Hospital, Via Battisti 192, Acquaviva delle Fonti, 74121, Taranto, Italy. basile.miulli@libero.it.ORCID 0000-0001-8152-5471
Alberto OrtizFRIAT and REDINREN, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain.ORCID 0000-0002-9805-9523
Sandip MitraManchester Academy of Health Sciences Centre, Manchester University Hospitals Foundation Trust and University of Manchester, Oxford Road, Manchester, UK.
Dimitrios KirmizisDepartment of Nephrology, Colchester General Hospital, Essex, UK.
Mehmet KanbayDepartment of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey.
Andrew DavenportDivision of Medicine, UCL Centre for Nephrology, Royal Free Hospital, University College London, London, UK.
Frank van der SandeDivision of Nephrology, Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands.
Adrian CovicNephrology Clinic, Dialysis and Renal Transplant Center-'C.I. Parhon' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.
EUDIAL Working Group of ERA-EDTA
Grigore T. Popa University of Medicine and Pharmacy · ROKoç University · TRMaastricht University Medical Centre · NLManchester Academic Health Science Centre · GBAssociazione Italiana Di Oncologia Medica · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality among patients with end-stage renal disease (ESRD). Clustering of traditional atherosclerotic and non-traditional risk factors drive the excess rates of coronary and non-coronary CVD in this population. The incidence, severity and mortality of coronary artery disease (CAD) as well as the number of complications of its therapy is higher in dialysis patients than in non-chronic kidney disease patients. Given the lack of randomized clinical trial evidence in this population, current practice is informed by observational data with a significant potential for bias. Furthermore, guidelines lack any recommendation for these patients or extrapolate them from trials performed in non-dialysis patients. Patients with ESRD are more likely to be asymptomatic, posing a challenge to the correct identification of CAD, which is essential for appropriate risk stratification and management. This may lead to "therapeutic nihilism", which has been associated with worse outcomes. Here, the ERA-EDTA EUDIAL Working Group reviews the diagnostic work-up and therapy of chronic coronary syndromes, unstable angina/non-ST elevation and ST-elevation myocardial infarction in dialysis patients, outlining unclear issues and controversies, discussing recent evidence, and proposing management strategies. Indications of antiplatelet and anticoagulant therapies, percutaneous coronary intervention and coronary artery bypass grafting are discussed. The issue of the interaction between dialysis session and myocardial damage is also addressed.

Indexed as

Coronary Artery DiseasePercutaneous Coronary InterventionAngina, UnstableCoronary Artery BypassHumansObservational Studies as TopicRenal DialysisChronic coronary syndromeChronic kidney diseaseCoronary artery diseaseDialysisEnd-stage renal diseaseMyocardial infarction

Identifiers

PMID32472526
OpenAlexW3031371436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.