SynthesisJournal of assisted reproduction and genetics2020
Is the probability of pregnancy after ovarian stimulation for IVF associated with serum estradiol levels on the day of triggering final oocyte maturation with hCG? A systematic review and meta-analysis.
Synthesis in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- ESHRE guideline: ovarian stimulation for IVF/ICSI: an update in 2025†.Human reproduction (Oxford, England) · 2026Guideline
- Outcomes after assisted reproductive technology in women with cancer: a systematic review and meta-analysis.Human reproduction (Oxford, England) · 2023Pooled it
- Magnitude of Post-Retrieval Estradiol Decline Directly Compromises Clinical Pregnancy and Live Birth Rates in High Responders Undergoing IVF/ICSI cycles with antagonist protocols.Journal of assisted reproduction and genetics · 2026Article
- Association of estradiol and progesterone levels on human chorionic gonadotropin day with pregnancy outcomes in IVF/ICSI fresh embryo transfer.Frontiers in endocrinology · 2026Article
- Impact of estradiol-to-progesterone ratio before progesterone initiation on pregnancy outcomes in frozen embryo transfer cycles with hormone replacement therapy: an analysis of over 25,000 cycles.Frontiers in endocrinology · 2026Article
- Effect of hCG day's estradiol levels on pregnancy outcomes following GnRH antagonist protocol: a retrospective study of 3192 fresh embryo transfer cycles.BMC pregnancy and childbirth · 2025Article
- Serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunity.Scientific reports · 2025Article
- Relationship Between Estradiol Levels Measured on the Initiation Day of GnRH Antagonist Treatment and Pregnancy Outcomes in Patients Receiving the Antagonist Protocol.Medicina (Kaunas, Lithuania) · 2025Article
- Machine learning algorithms in constructing prediction models for assisted reproductive technology (ART) related live birth outcomes.Scientific reports · 2024Article
- Combined analysis of estradiol and β-hCG to predict the early pregnancy outcome of FET: a retrospective study.Journal of ovarian research · 2024Article
- High estradiol levels in fresh embryo transfer cycles are not associated with detrimental impact on birth outcomes.Journal of assisted reproduction and genetics · 2024Article
- Estradiol-to-follicle ratio on human chorionic gonadotropin day is a novel predictor of gestational diabetes mellitus in women receiving fresh embryo transfer.Frontiers in endocrinology · 2024Article
- Live birth rate following a failed first in vitro fertilization cycle with no embryos for transfer.Scientific reports · 2023Article
- Effect of serum progesterone on human chorionic gonadotropin trigger day / metaphase II oocyte ratio on pregnancy and neonatal outcomes in women undergoing ICSI cycle.BMC pregnancy and childbirth · 2023Article
- The effect of peak serum estradiol level during ovarian stimulation on cumulative live birth and obstetric outcomes in freeze-all cycles.Frontiers in endocrinology · 2023Article
- Article
- Association between serum estradiol level on day of progesterone start and outcomes from frozen blastocyst transfer cycles utilizing oral estradiol.Journal of assisted reproduction and genetics · 2022Article
- The Association Between Serum Estradiol Levels on hCG Trigger Day and Live Birth Rates in Non-PCOS Patients: A Retrospective Cohort Study.Frontiers in endocrinology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe objective of this systematic review and metaanalysis was to examine if the probability of pregnancy after ovarian stimulation for in vitro fertilization (IVF), using GnRH analogues and gonadotrophins is associated with serum estradiol level (Ε
methodsTwenty-one studies were eligible for this systematic review, including 19,598 IVF cycles, whereas three studies were eligible for metaanalysis, including 641 IVF cycles. The main outcome measure was achievement of ongoing pregnancy/live birth and, if not available, clinical pregnancy or biochemical pregnancy.
resultsPooling of data showed no differences in the probability of clinical pregnancy between patients with high and low Ε
conclusionCurrently, there is insufficient evidence to support or deny the presence of an association between the probability of pregnancy and serum Ε
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.