Evidence map›Paper›PMID 32472387›Full record

ArticleEuropean journal of nutrition2021

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer's disease.

L M P Wesselman, D Melo van Lent, A Schröder, O van de Rest, O Peters, F Menne, M Fuentes, J Priller, E J Spruth, S Altenstein and 26 more

Abstract read
In one paragraph

Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  14. The association of MIND diet with cognitive resilience to neuropathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

L M P Wesselman *German Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. l.wesselman@amsterdamumc.nl.ORCID http://orcid.org/0000-0001-6758-4504
D Melo van Lent *German Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0002-7392-9289
A SchröderGerman Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
O van de RestDivision of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands.ORCID http://orcid.org/0000-0002-4632-7418
O PetersGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
F MenneCharité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Hindenburgdamm 30, 12203, Berlin, Germany.ORCID http://orcid.org/0000-0003-1574-4443
M FuentesCharité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Hindenburgdamm 30, 12203, Berlin, Germany.
J PrillerGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
E J SpruthGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
S AltensteinDepartment of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117, Berlin, Germany.
A SchneiderGerman Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
K FließbachGerman Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
S RoeskeGerman Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
S WolfsgruberGerman Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
L KleineidamGerman Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
A SpottkeGerman Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
V ProssStudy Center Bonn, Medical Faculty, Venusberg-Campus 1, 53127, Bonn, Germany.
J WiltfangGerman Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.
R VukovichGerman Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.
A K SchildGerman Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
E DüzelGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
C D MetzgerGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
W GlanzGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
K BuergerGerman Center for Neurodegenerative Diseases (DZNE, Munich), Feodor-Lynen-Strasse 17, 81377, Munich, Germany.
D JanowitzInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Feodor-Lynen-Strasse 17, 81377, Munich, Germany.
R PerneczkyGerman Center for Neurodegenerative Diseases (DZNE, Munich), Feodor-Lynen-Strasse 17, 81377, Munich, Germany.
M TatòGerman Center for Neurodegenerative Diseases (DZNE, Munich), Feodor-Lynen-Strasse 17, 81377, Munich, Germany.
S TeipelGerman Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
I KilimannGerman Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
C LaskeGerman Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
M BuchmannGerman Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
A RamirezDepartment of Psychiatry, University of Cologne, Medical Faculty, Kerpener Strasse 62, 50924, Cologne, Germany.
S A M SikkesDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-0161-3656
F JessenGerman Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
W M van der FlierDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-8766-6224
M WagnerGerman Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0003-2589-6440

Funding

Alzheimer Forschung Initiative International Research GrantEU Joint Programme - Neurodegenerative Disease Research JPND_PS_FP-689-019; ZonMw grant no. 733051043German Federal Ministry of Education and Research BMBF; grant 01EA1809CNWO-FCB NUDAD; project number 057-14-004Stichting Equilibrio research grant
6 · The paper itself

Abstract

purposeTo investigate cross-sectional associations between dietary patterns and cognitive functioning in elderly free of dementia.

methodsData of 389 participants from the German DELCODE study (52% female, 69 ± 6 years, mean Mini Mental State Score 29 ± 1) were included. The sample was enriched with elderly at increased risk for Alzheimer's disease (AD) by including participants with subjective cognitive decline, mild cognitive impairment (MCI) and siblings of AD patients. Mediterranean and MIND diets were derived from 148 Food Frequency Questionnaire items, and data-driven patterns by principal component analysis (PCA) of 39 food groups. Associations between dietary patterns and five cognitive domain scores were analyzed with linear regression analyses adjusted for demographics (model 1), and additionally for energy intake, BMI, other lifestyle variables and APOe4-status (model 2). For PCA-derived dietary components, final model 3 included all other dietary components.

resultsIn fully adjusted models, adherence to Mediterranean and MIND diet was associated with better memory. The 'alcoholic beverages' PCA component was positively associated with most cognitive domains. Exclusion of MCI subjects (n = 60) revealed that Mediterranean and MIND diet were also related to language functions; associations with the alcoholic beverages component were attenuated, but most remained significant.

conclusionIn line with data from elderly population samples, Mediterranean and MIND diet and some data-derived dietary patterns were related to memory and language function. Longitudinal data are needed to draw conclusions on the putative effect of nutrition on the rate of cognitive decline, and on the potential of dietary interventions in groups at increased risk for AD.

Indexed as

Alzheimer DiseaseCognitive DysfunctionDiet, MediterraneanAgedCognitionCross-Sectional StudiesFemaleHumansMaleCognitionDementiaDietary patternsMediterranean dietMIND diet

Identifiers

PMID32472387
PMCPMC7900077

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