Evidence map›Paper›PMID 32472323›Full record

ArticleMolecular and cellular biochemistry2020

Association of estrogen receptor β polymorphisms with posterior tibial tendon dysfunction.

P R B Nogara, A L Godoy-Santos, F C P Fonseca, C Cesar-Netto, K C Carvalho, E C Baracat, N Maffulli, P A Pontin, M C L Santos

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In one paragraph

Article in Molecular and cellular biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Contribution of insulin‑like growth factor‑1 to tendon repair (Review).International journal of molecular medicine · 2025
    Review
  6. The tendon unit: biochemical, biomechanical, hormonal influences.Journal of orthopaedic surgery and research · 2023
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

P R B NogaraDepartment of Cell Biology, University Federal of Paraná, Curitiba, PR, Brazil.
A L Godoy-SantosDepartment of Orthopaedics, Foot and Ankle Service, University of São Paulo, São Paulo, SP, Brazil.
F C P FonsecaDepartment of Orthopaedics, Foot and Ankle Service, University of São Paulo, São Paulo, SP, Brazil.
C Cesar-NettoDepartment of Orthopedic, Medstar Union Memorial Hospital, Baltimore, USA.
K C CarvalhoDepartment of Gynecology, University of São Paulo, São Paulo, SP, Brazil.
E C BaracatDepartment of Gynecology, University of São Paulo, São Paulo, SP, Brazil.
N MaffulliCentre for Sports and Exercise Medicine Barts and The London, School of Medicine and Dentistry, London, UK.
P A PontinDepartment of Orthopaedics, Foot and Ankle Service, University of São Paulo, São Paulo, SP, Brazil.
M C L SantosDepartment of Cell Biology, University Federal of Paraná, Curitiba, PR, Brazil. lemegsantos@gmail.com.ORCID http://orcid.org/0000-0002-0507-1604
Universidade de São Paulo · BRUniversidade Federal do Paraná · BRMedStar Union Memorial Hospital · USUniversity of Salerno · IT

Funding

Capes 400001016/007p8
6 · The paper itself

Abstract

Posterior tibial tendon (PTT) dysfunction is three times more common in females, and some patients may have a predisposition without a clinically evident cause, suggesting that individual characteristics play an important role in tendinopathy. The present study investigated the association of rs4986938 (+ 1730G > A; AluI RFLP) and rs1256049 (- 1082G > A; RsaI RFLP) single nucleotide polymorphisms (SNPs) of estrogen receptor-beta (ER-β) gene with PTT dysfunction. A total of 400 participants were recruited. The PTT dysfunction group: these patients underwent surgery, with PTT tendinopathy confirmed by histopathology and magnetic resonance image (MRI). The control group was composed of participants with no clinical or MRI evidence of PTT dysfunction. Each group was composed of 100 postmenopausal women, 50 premenopausal women, and 50 men. Genomic DNA was extracted from saliva samples, and genotypes were obtained by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Concerning the ER-β SNP rs4986938, there were significant differences in the frequencies of alleles between test and control groups of all the cases, only postmenopausal women and only men (p < 0.0001, p = 0.0016 and p = 0.0001). Considering the PTT dysfunction group and comparing postmenopausal women versus premenopausal women adding men, the analysis showed significant differences in the allelic distribution (p = 0.0450): the allele A in postmenopausal women is a risk factor. The ER-β SNP rs1256049 did not show differences in the frequencies of alleles and genotypes between groups. The ER-β SNP rs4986938, but not ER -β SNPs rs1256049, may contribute to PTT insufficiency in the Brazilian population, with additional risk in postmenopausal women. Addition, in men the genetic factor could be more determinant.

Indexed as

AdultAllelesCase-Control StudiesCross-Sectional StudiesEstrogen Receptor betaFemaleGene FrequencyGenetic Predisposition to DiseaseHumansMaleMiddle AgedPolymorphism, Restriction Fragment LengthPolymorphism, Single NucleotidePosterior Tibial Tendon DysfunctionPostmenopauseTendinopathyESR2 protein, humanEstrogen Receptor betaEstrogen receptorGenetic polymorphismRisk factorTendinopathy

Identifiers

PMID32472323
OpenAlexW3032551453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.