Novel Mannich base 3FB3FA8H induces apoptosis by upregulating P53 pathway in neuroblastoma cells.

Syed Saad Hussain, Shaheen Faizi, Kinza Rafi, Shabana U Simjee

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In one paragraph

Article in Molecular and cellular biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

0.1field-weighted citation impact, top 56% of its field

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1 citing paper in PubMed, 3 citations in OpenAlex.

Effects of transcription factorAnnals of surgical treatment and research · 2024
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5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Syed Saad HussainH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Shaheen FaiziH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Kinza RafiDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Shabana U SimjeeH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. shabana.simjee@iccs.edu.ORCID http://orcid.org/0000-0001-9675-842X

University of Karachi · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

P53 plays an important role in maintaining genetic stability and development of resistance against tumors. Dysregulation of P53 gene is one of the key factors contributing to the etiology of neuroblastoma which causes cells to evade apoptosis. Activating P53 pathway can be a therapeutic alternative to the currently available medicinal strategies. Mannich bases have been known to possess various biological activities including the anticancer activity. In this study, we have targeted the P53 pathway by novel Mannich base (3FB3FA8H) which can be a future prospect to cure neuroblastoma. 3FB3FA8H has shown modulation of P53 pathway leading to apoptosis of neuroblastoma cells. Mitochondrial membrane permeability is also increased by 3FB3FA8H which may be a consequence of P53 pathway modulation. 3FB3FA8H increases the mRNA levels of P53 leading to activation of BAX. Inclining BAX/BCL2 ratio towards apoptotic BAX leads to cleavage of caspase 3, ultimately, causing apoptosis. Series of experiments provide the evidence that Mannich base 3FB3FA8H leads to P53-mediated apoptosis. Inducing apoptosis by this mechanism could be of central importance in reducing tumor burden which can be a good prospect for neuroblastoma patients.

Indexed as

Antineoplastic AgentsApoptosisbcl-2-Associated X ProteinCaspase 3Cell Line, TumorFluorobenzenesHumansHydroxyquinolinesMannich BasesMitochondrial MembranesNeuroblastomaSignal TransductionTumor Suppressor Protein p53Up-RegulationAntineoplastic AgentsBAX protein, humanbcl-2-Associated X ProteinCASP3 protein, humanCaspase 3FluorobenzenesHydroxyquinolinesMannich BasesTP53 protein, humanTumor Suppressor Protein p53ApoptosisMannich baseNeuroblastomaNuclear area factorP53

Identifiers

PMID32472321

DOI10.1007/s11010-020-03755-1

OpenAlexW3030235398

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.