ArticleDiabetologia2020
Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study.
Erratum issued 2 registry-linked trialsOpen access · hybridAbstract readMulticenter Study
In one paragraph
Article in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 482 papers, 24 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
482citing papers in PubMed, 24 pooled it
19.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
"Coronavirus SARS-CoV2 and Diabetes Outcomes" : CORONADO
Effect of the Combination of Dipeptidyl Peptidase-4 Inhibitor (DPP4i) and Insulin in Comparison to Insulin on Metabolic Control and Prognosis in Hospitalized Patients With COVID-19
Who cites it
482 citing papers in PubMed, 24 syntheses or guidelines pooled it, 834 citations in OpenAlex.
- Diabetes Mellitus and COVID-19 in Adults: A Systematic Review of Pathophysiological Connections, Clinical Outcomes, and Therapeutic Considerations.International journal of molecular sciences · 2026Pooled it
- The Effect of Antihyperglycemic Medications on COVID-19: A Meta-analysis and Systematic Review from Observational Studies.Therapeutic innovation & regulatory science · 2024 · on this mapPooled it
- Risk phenotypes of diabetes and association with COVID-19 severity and death: an update of a living systematic review and meta-analysis.Diabetologia · 2023Pooled it
- Obesity as an independent risk factor for COVID-19 severity and mortality.The Cochrane database of systematic reviews · 2023Pooled it
- Global Diabetes Prevalence in COVID-19 Patients and Contribution to COVID-19- Related Severity and Mortality: A Systematic Review and Meta-analysis.Diabetes care · 2023Pooled it
- Noninsulin-based antihyperglycemic medications in patients with diabetes and COVID-19: A systematic review and meta-analysis.Journal of diabetes · 2023 · on this mapPooled it
- Association between COVID-19 and sexual health: an umbrella review.Annals of medicine · 2023Pooled it
- Is metformin use associated with low mortality in patients with type 2 diabetes mellitus hospitalized for COVID-19? a multivariable and propensity score-adjusted meta-analysis.PloS one · 2023 · on this mapPooled it
- Association of Glucose-Lowering Drugs With Outcomes in Patients With Diabetes Before Hospitalization for COVID-19: A Systematic Review and Network Meta-analysis.JAMA network open · 2022Pooled it
- The association between macrovascular complications and intensive care admission, invasive mechanical ventilation, and mortality in people with diabetes hospitalized for coronavirus disease-2019 (COVID-19).Cardiovascular diabetology · 2022Pooled it
- In-hospital hyperglycemia but not diabetes mellitus alone is associated with increased in-hospital mortality in community-acquired pneumonia (CAP): a systematic review and meta-analysis of observational studies prior to COVID-19.BMJ open diabetes research & care · 2022Pooled it
- Renin-Angiotensin Aldosterone System Inhibitors and COVID-19: A Systematic Review and Meta-Analysis Revealing Critical Bias Across a Body of Observational Research.Journal of the American Heart Association · 2022Pooled it
- Significant association of obstructive sleep apnoea with increased risk for fatal COVID-19: A quantitative meta-analysis based on adjusted effect estimates.Sleep medicine reviews · 2022Pooled it
- Does metformin affect outcomes in COVID-19 patients with new or pre-existing diabetes mellitus? A systematic review and meta-analysis.British journal of clinical pharmacology · 2022 · on this mapPooled it
- Pre-existing diabetic retinopathy as a prognostic factor for COVID-19 outcomes amongst people with diabetes: A systematic review.Diabetes research and clinical practice · 2022Pooled it
- Association of statin and/or renin-angiotensin-aldosterone system modulating therapy with mortality in adults with diabetes admitted to hospital with COVID-19: A retrospective multicentre European study.Diabetes & metabolic syndrome · 2022 · on this mapPooled it
- Impact of diabetes on COVID-19 mortality and hospital outcomes from a global perspective: An umbrella systematic review and meta-analysis.Endocrinology, diabetes & metabolism · 2022Pooled it
- The negative impact of obesity on the occurrence and prognosis of the 2019 novel coronavirus (COVID-19) disease: a systematic review and meta-analysis.Eating and weight disorders : EWD · 2022Pooled it
- The Association Between Antidiabetic Agents and Clinical Outcomes of COVID-19 Patients With Diabetes: A Bayesian Network Meta-Analysis.Frontiers in endocrinology · 2022 · on this mapPooled it
- Association of serum C-reactive protein (CRP) and D-dimer concentration on the severity of COVID-19 cases with or without diabetes: a systematic review and meta-analysis.Expert review of endocrinology & metabolism · 2022Pooled it
422 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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- Erratum issued
Authors and funding
41 authors at 20 institutions in 1 country.
Bertrand CariouDépartement d'Endocrinologie, Diabétologie et Nutrition, l'institut du thorax, Inserm, CNRS, UNIV Nantes, CHU Nantes, Hôpital Guillaume et René Laennec, 44093, Nantes Cedex 01, France. bertrand.cariou@univ-nantes.fr.ORCID https://orcid.org/0000-0002-1580-8040
Samy HadjadjDépartement d'Endocrinologie, Diabétologie et Nutrition, l'institut du thorax, Inserm, CNRS, UNIV Nantes, CHU Nantes, Hôpital Guillaume et René Laennec, 44093, Nantes Cedex 01, France. samy.hadjadj@univ-nantes.fr.ORCID https://orcid.org/0000-0001-7110-6994
Matthieu WargnyDépartement d'Endocrinologie, Diabétologie et Nutrition, l'institut du thorax, Inserm, CNRS, UNIV Nantes, CHU Nantes, Hôpital Guillaume et René Laennec, 44093, Nantes Cedex 01, France.ORCID https://orcid.org/0000-0001-6027-9486
Matthieu PichelinDépartement d'Endocrinologie, Diabétologie et Nutrition, l'institut du thorax, Inserm, CNRS, UNIV Nantes, CHU Nantes, Hôpital Guillaume et René Laennec, 44093, Nantes Cedex 01, France.ORCID https://orcid.org/0000-0002-6822-6132
Abdallah Al-SalamehDépartement d'Endocrinologie, Diabétologie et Nutrition, CHU Amiens, PeriToxUMR_I 01, Université de Picardie, Amiens, France.ORCID https://orcid.org/0000-0002-7951-9926
Ingrid AllixDépartement d'Endocrinologie, Diabétologie, Nutrition, CHU de Angers, Angers, France.
Coralie AmadouDépartement de Diabétologie, Centre Hospitalier Sud Francilien, Corbeil Essonne, France.ORCID https://orcid.org/0000-0002-0581-7592
Gwénaëlle ArnaultDépartement d'Endocrinologie, Diabétologie et Maladies Métaboliques, Centre Hospitalier Bretagne Atlantique, Vannes, France.
Florence BaudouxClinique d'Endocrinologique Marc-Linquette, Hôpital Claude-Huriez, CHRU de Lille, Lille, France.
Bernard BauduceauDépartement de Diabétologie, H.I.A. Begin, Saint Mandé, France.
Sophie BorotDépartement d'Endocrinologie, Diabétologie et Nutrition, CHU de Besançon, Besançon, France.ORCID https://orcid.org/0000-0001-6240-8253
Muriel Bourgeon-GhittoriDépartement d'Endocrinologie, Diabétologie et Nutrition, Assistance Publique Hôpitaux de Paris, Université Paris Saclay, Hôpital Antoine Béclère, Clamart, Hôpital Bicêtre, Le Kremlin Bicêtre, France.
Olivier BourronSorbonne Université, Assistance Publique Hôpitaux de Paris, Département de Diabétologie, CHU La Pitié Salpêtrière-Charles Foix, Inserm, UMR_S 1138, Centre de Recherche des Cordeliers, Paris 06, Institute of Cardiometabolism and Nutrition ICAN, Paris, France.ORCID https://orcid.org/0000-0001-7348-7161
David BoutoilleDépartement des Maladies Infectieuses et Tropicales, CHU Nantes, Nantes, France.ORCID https://orcid.org/0000-0001-9722-2029
France Cazenave-RoblotDépartement des Maladies Infectieuses et Tropicales, CHU de Poitiers, INSERM U1070, Poitiers, France.ORCID https://orcid.org/0000-0003-4325-023X
Claude ChaumeilFédération Française des Diabétiques (FFD), Paris, France.
Emmanuel CossonAssistance Publique Hôpitaux de Paris, Hôpital Avicenne, Université Paris 13, Sorbonne Paris Cité, Département d'Endocrinologie, Diabétologie et Nutrition, CRNH-IdF, CINFO, Bobigny, France.ORCID https://orcid.org/0000-0002-8785-3385
Sandrine CoudolCIC-EC 1413, Clinique des Données, CHU Nantes, Nantes, France.
Patrice DarmonDépartement d'Endocrinologie et de Diabétologie, Hôpital de la Conception, Assistance Publique Hôpitaux de Marseille, Marseille, France.ORCID https://orcid.org/0000-0003-1726-2296
Emmanuel DisseDépartement d'Endocrinologie, Diabétologie et Nutrition, Hospices Civils de Lyon, CarMeN Laboratory, Inserm 1060, Lyon, France, Université Claude Bernard Lyon 1, Lyon, France.ORCID https://orcid.org/0000-0002-4045-0503
Amélie Ducet-BoiffardDépartement d'Endocrinologie et de Diabétologie, Centre Hospitalier Départemental de Vendée, La Roche sur Yon, France.
Bénédicte GaboritDépartement d'Endocrinologie et de Diabétologie, Hôpital Nord, Assistance Publique Hôpitaux de Marseille, Marseille, France.ORCID https://orcid.org/0000-0002-4180-158X
Michael JoubertDépartement de Diabétologie, CHU de Caen, Caen, France.ORCID https://orcid.org/0000-0002-8731-7355
Véronique KerlanDépartement d'Endocrinologie, CHU de Brest, EA 3878 GETBO, Brest, France.
Bruno LaviolleUniversité de Rennes, CHU Rennes, Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), Rennes, France.ORCID https://orcid.org/0000-0002-9541-6708
Lucien MarchandDépartement d'Endocrinologie et de Diabétologie, Centre Hospitalier St. Joseph - St. Luc, Lyon, France.ORCID https://orcid.org/0000-0001-9101-5002
Laurent MeyerDépartement d'Endocrinologie, Diabétologie et Nutrition, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0003-3687-5522
Louis PotierDépartement d'Endocrinologie, Diabétologie et Nutrition, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Centre de Recherche des Cordeliers, Inserm, U-1138, Université de Paris, Paris, France.ORCID https://orcid.org/0000-0001-6268-7360
Gaëtan PrevostDépartement d'Endocrinologie, Diabétologie et Maladies Métaboliques, CHU de Rouen, Université de Rouen, Rouen, France.
Jean-Pierre RivelineDépartement Diabète et Endocrinologie, Hôpital Lariboisière, Assistance Publique Hôpitaux de Paris, Paris, France.ORCID https://orcid.org/0000-0001-7991-0741
René RobertUniversité de Poitiers, CIC Inserm 1402, Poitiers, Médecine Intensive Réanimation, Poitiers, France.ORCID https://orcid.org/0000-0001-5989-5409
Pierre-Jean SaulnierCentre d'Investigation Clinique CIC 1402, Université de Poitiers, Inserm, CHU de Poitiers, Poitiers, France.ORCID https://orcid.org/0000-0003-1862-4252
Ariane SultanDépartement d'Endocrinologie, Diabète, Nutrition et CIC Inserm 1411, CHU de Montpellier, Montpellier, France.ORCID https://orcid.org/0000-0002-9540-8222
Jean-François ThébautFédération Française des Diabétiques (FFD), Paris, France.ORCID https://orcid.org/0000-0003-4926-9943
Charles ThivoletCentre du Diabète DIAB-eCARE, Hospices Civils de Lyon et Laboratoire CarMeN, Inserm, INRA, INSA, Université Claude Bernard Lyon 1, Lyon, France.ORCID https://orcid.org/0000-0002-0696-974X
Blandine TramuntDépartement d'Endocrinologie, Diabétologie et Nutrition, CHU Toulouse, Institut des Maladies Métaboliques et Cardiovasculaires, UMR1048 Inserm/UPS, Université de Toulouse, Toulouse, France.
Camille VatierAssistance Publique Hôpitaux de Paris, Saint-Antoine Hospital, Reference Center of Rare Diseases of Insulin Secretion and Insulin Sensitivity (PRISIS), Department of Endocrinology, Paris, France.ORCID https://orcid.org/0000-0001-8342-1596
Ronan RousselDépartement d'Endocrinologie, Diabétologie et Nutrition, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Centre de Recherche des Cordeliers, Inserm, U-1138, Université de Paris, Paris, France.ORCID https://orcid.org/0000-0003-2292-8363
Jean-François GautierDépartement Diabète et Endocrinologie, Hôpital Lariboisière, Assistance Publique Hôpitaux de Paris, Paris, France.ORCID https://orcid.org/0000-0001-6458-2001
Pierre GourdyDépartement d'Endocrinologie, Diabétologie et Nutrition, CHU Toulouse, Institut des Maladies Métaboliques et Cardiovasculaires, UMR1048 Inserm/UPS, Université de Toulouse, Toulouse, France.ORCID https://orcid.org/0000-0002-5362-3813
CORONADO investigators
Inserm · FRCentre National de la Recherche Scientifique · FRAssistance Publique Hôpitaux de Marseille · FRFédération française de cardiologie · FRUniversité Claude Bernard Lyon 1 · FRUniversité Toulouse III - Paul Sabatier · FRCentre d'Investigation Clinique de Nantes · FRCentre hospitalier Bretagne Atlantique · FRCentre Hospitalier Départemental Vendée · FRCentre Hospitalier Régional Universitaire de Brest · FRCentre Hospitalier Saint-Joseph Saint-Luc · FRCentre Hospitalier Sud Francilien · FRCentre Hospitalier Universitaire Amiens-Picardie · FRCentre Hospitalier Universitaire d'Angers · FRCentre Hospitalier Universitaire de Besançon · FRCentre Hospitalier Universitaire de Caen Normandie · FRCentre Hospitalier Universitaire de Lille · FRConservatoire National des Arts et Métiers · FRHôpital d'Instruction des Armées Bégin · FRHôpitaux Universitaires de Strasbourg · FR
Funding
Air Liquide CORONADO Initiative Emergency grantFondation Francophone pour la Recherche sur le Diabète CORONADO Initiative Emergency GrantSociéte Francophone du Diabète CORONADO Initiative Emergency Grant
Abstract
aims/hypothesisCoronavirus disease-2019 (COVID-19) is a life-threatening infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Diabetes has rapidly emerged as a major comorbidity for COVID-19 severity. However, the phenotypic characteristics of diabetes in COVID-19 patients are unknown.
methodsWe conducted a nationwide multicentre observational study in people with diabetes hospitalised for COVID-19 in 53 French centres in the period 10-31 March 2020. The primary outcome combined tracheal intubation for mechanical ventilation and/or death within 7 days of admission. Age- and sex-adjusted multivariable logistic regressions were performed to assess the prognostic value of clinical and biological features with the endpoint. ORs are reported for a 1 SD increase after standardisation.
resultsThe current analysis focused on 1317 participants: 64.9% men, mean age 69.8 ± 13.0 years, median BMI 28.4 (25th-75th percentile: 25.0-32.7) kg/m CONCLUSIONS/INTERPRETATIONS: In people with diabetes hospitalised for COVID-19, BMI, but not long-term glucose control, was positively and independently associated with tracheal intubation and/or death within 7 days.
trial registrationclinicaltrials.gov NCT04324736.
Indexed as
AgedAged, 80 and overCoronavirus InfectionsCOVID-19Diabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansHypertensionInpatientsMaleMiddle AgedPandemicsPneumonia, ViralPrognosisRespiration, ArtificialGlycated Hemoglobinhemoglobin A1c protein, humanBMICOVID-19DeathDiabetesHbA1cHypertensionMechanical ventilation
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT04324736ClinicalTrials.gov
NCT04542213ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.