ArticleScientific reports2020
Two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
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- Protecting episodic memory after sleep loss: Similar benefits of exercise and naps via distinct neural contributions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A neural signature of sleep deprivation in the human brain.Nature communications · 2026Article
- Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Short sleep recovery partially restores decision-making alterations induced by total sleep deprivation.Sleep advances : a journal of the Sleep Research Society · 2026Article
- A Sleeping Opportunity Does Not Restore Hippocampal Alterations Induced by 10 Days of Sleep Restriction in Rats.Neurochemical research · 2025Article
- Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults.Molecular psychiatry · 2025Article
- Molecular basis identification and hypnotic drug interactions for cognitive impairment related to sleep deprivation.BMC psychiatry · 2025Article
- microRNA-218-5p coordinates scaling of excitatory and inhibitory synapses during homeostatic synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Nighttime is the right time: the time interval to overnight sleep following an embarrassing experience does not influence long-term emotional responses to its reactivated episode.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Sleep is necessary for experience-dependent sequence plasticity in mouse primary visual cortex.Sleep · 2025Article
- Exploring the Correlation Between Sleep Chronotype and the Volumes of Subcortical Structures and Hippocampal Subfields in Young Healthy Population.Brain sciences · 2025Article
- The relationship between physical activity, sleep, and negative emotions in physically weak college students.Frontiers in public health · 2025Article
- Can sleep affect destination memory? A prospective narrative review.Frontiers in psychology · 2025Review
- Chronic Sleep Deprivation Altered the Expression of Memory-Related Genes and Caused Cognitive Memory Dysfunction in Mice.International journal of molecular sciences · 2024Article
- Five percent CONeuroprotection (Chichester, England) · 2024Article
- The influence of sleep disorders on perioperative neurocognitive disorders among the elderly: A narrative review.Ibrain · 2024Review
- Functional connectomics in depression: insights into therapies.Trends in cognitive sciences · 2023Review
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
Sleep deprivation significantly impairs a range of cognitive and brain function, particularly episodic memory and the underlying hippocampal function. However, it remains controversial whether one or two nights of recovery sleep following sleep deprivation fully restores brain and cognitive function. In this study, we used functional magnetic resonance imaging (fMRI) and examined the effects of two consecutive nights (20-hour time-in-bed) of recovery sleep on resting-state hippocampal connectivity and episodic memory deficits following one night of total sleep deprivation (TSD) in 39 healthy adults in a controlled in-laboratory protocol. TSD significantly reduced memory performance in a scene recognition task, impaired hippocampal connectivity to multiple prefrontal and default mode network regions, and disrupted the relationships between memory performance and hippocampal connectivity. Following TSD, two nights of recovery sleep restored hippocampal connectivity to baseline levels, but did not fully restore memory performance nor its associations with hippocampal connectivity. These findings suggest that more than two nights of recovery sleep are needed to fully restore memory function and hippocampal-memory associations after one night of total sleep loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.